母乳胃肠肽表达与其过敏症的临床分析

发布时间：2018-02-28 21:02

本文关键词： 母乳喂养食物过敏生长抑素胃动素　出处：《四川大学学报(医学版)》2017年01期 　论文类型：期刊论文

【摘要】：目的分析母乳过敏症患儿的临床特征及母乳中生长抑素(SST)及胃动素(MTL)的含量变化,探讨母乳过敏的可能原因。方法收集23例母乳过敏症患儿临床资料,总结临床表现,分析临床实验室检查结果。并收集患儿大便及母乳,以23例正常婴儿作对照,放射免疫法检测大便及母乳中SST与MTL含量。结果大便中SST与MTL含量(pg/mg)分别为:患儿组32.6±8.9,2.3±3.7;对照组56.2±12.7,21.6±4.7;两组间差异有统计学意义(P0.05)。母乳中SST、MTL含量(pg/mg)分别为:患儿组236.7±28.9,159.4±36.7;对照组412.6±36.7,216.8±59.7;两组间差异有统计学意义(P0.05)。患儿中有腹泻的占91.3%(20/23),呕吐的占86.9%(21/23),血便的占69.6%(16/23)。其中95.7%(22/23)有C-反应蛋白(CRP)增高,87.0%(20/23)大便隐血阳性,73.9%(17/23)外周血相升高,39.1%(9/23)有大便白细胞。胃肠镜下以表浅糜烂渗血多见,肠镜下83.3%(10/12)有淋巴增生及浸润,嗜酸粒细胞浸润占25.0%(3/12)。结论对临床上消化道症状迁延不愈的纯母乳喂养婴儿,要警惕母乳过敏症的可能。母乳中SST与MTL含量的降低可能是母乳过敏的原因之一。
[Abstract]:Objective to analyze the clinical characteristics and changes of somatostatin (SST) and motilin motilin (MTL) in breast milk of children with breast milk allergy, and to explore the possible causes of breast milk allergy. Methods the clinical data of 23 children with breast milk hypersensitivity were collected and the clinical manifestations were summarized. To analyze the results of clinical laboratory examination and collect the feces and breast milk of children, 23 normal infants were used as control. Results the levels of SST and MTL in stool and breast milk were 32.6 卤8.9 卤2.3 卤3.7 in the stool group and 56.2 卤12.7 卤21.6 卤4.7 in the control group, respectively. The difference between the two groups was statistically significant (P 0.05). The difference between the two groups was statistically significant (P 0.05). The incidence of diarrhea was 91.33 / 20 / 23, that of vomiting was 86.9% / 23 / 23, and that of blood stool was 69.6% / 23 / 23.Among them, 95.722 / 23 (95. 722 / 23) had increased C-reactive protein CRP (87.0% 20 / 23). Under the microscope, superficial erosion and oozing of blood are common. There were lymphoproliferative and infiltrating in 10 / 12 of 83.3% of patients under enteroscopy. Eosinophilic granulocyte infiltration accounted for 25.0% of the total. Conclusion Breast-fed infants with clinical symptoms of upper digestive tract are breast-fed. Be aware of the possibility of breast milk allergy. The decrease of SST and MTL in breast milk may be one of the causes of breast milk allergy.
【作者单位】：四川大学华西第二医院神经消化儿科出生缺陷与相关妇儿疾病教育部重点实验室;
【基金】：国家自然科学基金(No.81170607)资助
【分类号】：R725.9

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