幼儿急疹合并中性粒细胞减少症的临床分析

发布时间：2018-03-05 15:33

本文选题：粒细胞减少症　切入点：幼儿急疹　出处：《重庆医科大学》2012年硕士论文　论文类型：学位论文

【摘要】：目的分析幼儿急疹合并中性粒细胞减少症的临床特点，为临床诊治提供参考依据。方法 1.回顾性分析2010年1月至2011年6月于重庆医科大学附属儿童医院内科住院治疗的40例幼儿急疹合并中性粒细胞减少症患儿的临床资料，对照组为随机抽取的40例上呼吸道感染合并中性粒细胞减少症患儿，年龄分布与研究组相当。 2.运用SPSS19.0分析整理数据，使用χ2检验、t检验及方差分析分析相关数据，P0.05有统计学意义。结果 1.研究组与对照组之间男女比例及年龄分布均无显著性差异（P0.05）。研究组男24例，女16例，1岁20例，1-3岁20例。 2.研究组与对照组发病季节，无显著性差异，均以春、夏季发病居多。 3.研究组与对照组发热程度，无显著性差异，，均以高热居多。研究组患儿皮疹均于热退当天或热退1天后出现。 4.研究组中各年龄组之间及性别之间发热持续时间无显著性差异（P0.05）。研究组与对照组发热持续时间无显著性差异(P0.05),研究组平均发热持续时间为3.05天，对照组为3.25天。 5.初始时间：从开始发热到病程中首次发现白细胞计数（white-blood-cell count, WBC）及中性粒细胞绝对值（AbsoluteNeutrophil count, ANC）降低的时间。持续时间：从发现WBC及ANC减少至其降至最低的时间。研究组与对照组的初始时间比较有显著性差异（P0.05）。研究组WBC及ANC降低均于发热1-2天后出现，平均1.27天，对照组于发热1-5天后出现，平均2.35天。研究组与对照组的持续时间无显著性差异（P0.05）,均于0-2天。 6.研究组与对照组在WBC及ANC降低程度上无显著性差异(P0.05)。 7.研究组与对照组在WBC恢复时间上有显著性差异（P0.05），研究组WBC平均恢复时间3.05天，对照组3.65天。研究组患儿出院时ANC尚未完全恢复至正常水平（平均住院日为4.8天），但较入院时明显上升，对照组ANC平均恢复时间为4.40天。两组ANC恢复至正常时间均较WBC恢复时间晚。 8.研究组中是否使用药物升白细胞治疗，在WBC恢复时间上无显著性差异（P0.05），在予升白细胞药物治疗的病例中，不同治疗方案在WBC恢复时间上均无显著性差异（P0.05）。结论幼儿急疹合并中性粒细胞减少症患儿以小于3岁男性患儿多见，好发于夏季，多为高热，皮疹多于热退当天或热退1天后出现。WBC及ANC水平降低于发热1-2天后出现。用药与否与WBC恢复时间无明显相关性。ANC恢复时间较WBC恢复时间稍慢。研究组WBC恢复时间短，说明幼儿急疹合并中性粒细胞减少症患儿预后好。
[Abstract]:objective
Analysis of the clinical characteristics of exanthema subitum with neutropenia, provides the reference for the clinical diagnosis and treatment.
Method
1. January 2010 to June 2011 were retrospectively analyzed in 40 cases of exanthema subitum children's Hospital Affiliated to Medical University Of Chongqing medical hospital treatment combined with neutropenia in children with clinical data, control group with neutropenia in 40 children with upper respiratory tract infection were randomly selected, age distribution and research group.
2. the data were analyzed by SPSS19.0 analysis, using the chi square 2 test, t test and analysis of variance analysis related data, P0.05 had statistical significance.
Result
1. there were no significant differences in male and female ratio and age distribution between the study group and the control group (P0.05). There were 24 male, 16 female, 1 year old and 20 cases and 20 cases 1-3 years old in the study group.
2. the onset season of the study group and the control group had no significant difference, all in spring and in summer.
3. the fever degree of the study group and the control group had no significant difference, all with high fever. The rash of the children in the study group appeared on the day of hot retreat or 1 days after the heat retreat.
4., there was no significant difference in the duration of fever between the different age groups and the gender in the study group (P0.05). There was no significant difference in the duration of fever between the study group and the control group (P0.05), the average duration of fever in the study group was 3.05 days, and the control group was 3.25 days.
5., the initial time: from the onset of fever to the first course of disease, the time of white-blood-cell count (WBC) and AbsoluteNeutrophil count (ANC) decrease. Duration: from the discovery of WBC and ANC to the lowest time.
The initial time of study group and control group had significant difference (P0.05). The study group WBC and ANC decreased both appeared in the fever for 1-2 days, an average of 1.27 days, in the control group after 1-5 days of fever, an average of 2.35 days. There was no significant difference between the duration of the study group and the control group (P0.05), both in 0-2 days.
6. there was no significant difference in the reduction of WBC and ANC between the study group and the control group (P0.05).
7. the study group and the control group there were significant differences in WBC recovery time (P0.05), the study group WBC the average recovery time of 3.05 days, the control group for 3.65 days. The children study group was ANC has not yet fully recovered to the normal level (the average duration of hospitalization was 4.8 days), but were significantly higher than those of control group were increased, ANC the average recovery time was 4.40 days. The two group ANC returned to normal time than WBC recovery time is late.
8. in the study group, there was no significant difference in the recovery time of WBC between the two groups (P0.05). There was no significant difference in the recovery time of WBC between different treatment regimens (P0.05).
conclusion
Exanthema subitum with neutropenia in children less than 3 year old male with rare, occur in the summer, more than high fever, rash or fever fever the day after 1 days of.WBC and ANC decreased in 1-2 days after medication and fever. And the recovery time of WBC was not related to.ANC recovery time WBC recovery time is slow. The study group WBC recovery time is short, that exanthema subitum with neutropenia in children with a good prognosis.

【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R725.1

【参考文献】