过敏性紫癜患儿粪便细菌代谢相关产物短链脂肪酸水平测定及其意义

发布时间：2018-03-05 16:00

  本文选题：过敏性紫癜　切入点：儿童　出处：《中国实用儿科杂志》2017年07期 　论文类型：期刊论文

【摘要】：目的测定过敏性紫癜(HSP)患儿粪便中细菌代谢相关产物短链脂肪酸水平并研究其意义。方法选取2014年6月至2015年1月昆明医科大学第一附属医院儿科确诊为HSP 27例患儿,其中男15例、女12例;平均年龄(9.0±2.8)岁。均符合中华医学会儿科学分会免疫学组推荐的HSP诊断标准。健康儿童28例为对照组,其中男16例,女12例;平均年龄(9.5±1.3)岁。收集保存HSP患儿急性期、恢复期和对照组的粪便标本。应用气相色谱技术定量测定对照组、HSP急性期组和恢复期组粪便中短链脂肪酸包括乙酸、丙酸、丁酸、异丁酸、异戊酸浓度。结果对照组、HSP急性期组和恢复期组粪便乙酸浓度(mol/g)分别为(6.04±2.15)×10~(-5)、(3.90±3.08)×10~(-5)和(4.73±3.95)×10~(-5),对照组与急性期组比较,对照组高于急性期组且差异有统计学意义(P0.05),而与恢复期组比较,差异无统计学意义(P0.05)。丁酸浓度分别为[4.53(2.68,5.47)]×10~(-5)、[1.48(0.14,3.78)]×10~(-5)和[0.93(0.31,1.75)]×10~(-5),对照组高于急性期组及恢复期,且均有统计学意义(P0.017)。丙酸浓度分别为[3.22(2.22,4.20)]×10~(-5)、[1.80(7.84,3.66)]×10~(-5)和[2.68(0.46,4.93)]×10~(-5),组间差异无统计学意义(P0.017)。异丁酸浓度分别为[0.19(0.07,0.30)]×10~(-5)、[0.17(0.08,0.59)]×10~(-5)和[0.14(0.03,0.30)]×10~(-5),异戊酸浓度分别为[0.13(0.04,0.19)]×10~(-5)、[0.13(0.06,0.32)]×10~(-5)和[0.09(0.02,0.23)]×10~(-5),组间差异无统计学意义(P0.017)。结论 HSP急性期患儿粪便乙酸、丁酸显著降低。恢复期粪便乙酸虽有升高,但仍未完全回到正常水平,而粪便中丁酸浓度更低。
[Abstract]:Objective to determine the allergic purpura (HSP) in children with fecal bacterial metabolic products of short chain fatty acid level and investigate its significance. Methods the pediatric diagnosis of the First Affiliated Hospital of Kunming Medical University from June 2014 to January 2015 27 HSP cases, including 15 cases of male, 12 female; the average age (9 + 2.8) years old. Are in line with Chinese medicine Subspecialty Group of immunology recommended diagnostic criteria of HSP. 28 healthy children as control group, 16 cases were male, 12 were female; the average age (9.5 + 1.3) years old. The collection and preservation of children with HSP in acute period, recovery period and stool specimens of the control group. The control group was determined quantitatively by gas chromatography, HSP acute group and recovery of short chain fatty acids in feces group including acetic acid, propionic acid, butyric acid and isobutyric acid, isovaleric acid concentration. Results in the control group, HSP group and acute phase group fecal acetate concentration recovery (mol/g) respectively (6.04 + 2.15) * 10~ (-5 (3.90). 卤3.08)脳10~(-5)鍜，

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