血清25-羟维生素D与过敏性紫癜发病风险关系的病例对照研究

发布时间：2018-03-05 19:12

本文选题：紫癜　切入点：过敏性　出处：《重庆医学》2017年08期 　论文类型：期刊论文

【摘要】：目的探讨人体血清25-羟维生素D[25(OH)D]与过敏性紫癜(HSP)发病风险的关系。方法采用酶联免疫吸附法检测53例HSP患者和161例随机对照儿童血清25(OH)D水平,并采用调查问卷收集研究对象基本资料。以214例研究对象的25(OH)D水平四分位数为依据将其分为4个区间,用Logistic回归模型评价各区间血清25(OH)D水平与HSP发病风险的关联程度。结果病例组血清25(OH)D水平中位数为11.40ng/mL,对照组为15.36ng/mL,两组差异有统计学意义(P0.05)。以最低浓度组即第1区间为参考水平,第2、3、4区间OR值及95%CI分别为0.468(0.341~0.771)、0.442(0.302~0.627)、0.339(0.199~0.501)。采用前进法对性别、抽血季节进行校正,校正后第2、3、4区间OR值及95%CI分别为0.459(0.333~0.741)、0.408(0.317~0.611)、0.387(0.221~0.517),25(OH)D水平的升高与HSP发病风险的下降存在线性相关(P0.05)。结论 HSP发病风险随血清25(OH)D水平的增高而降低,25(OH)D可能是HSP发病的一项保护因素。
[Abstract]:Objective to investigate the relationship between human serum 25-hydroxyvitamin D and the risk of Henoch-Schonlein purpura (HSPs). Methods the serum levels of 25OHH D in 53 patients with HSP and 161 children with random control were detected by enzyme-linked immunosorbent assay (Elisa). The basic data of the subjects were collected by questionnaire. Based on the 25 OHH D quartiles of 214 subjects, they were divided into 4 regions. The Logistic regression model was used to evaluate the correlation between the serum 25 OHH D level and the risk of HSP. Results the median of serum 25 OHH D level was 11.40 ng / mL in the case group and 15.36 ng / mL in the control group. The difference between the two groups was statistically significant (P 0.05). The reference level was the lowest concentration group (the first interval). The OR value and 95 CI of interval 2 / 3 / 4 were 0.468 / 0.341/ 0.771/ 0.442t / 0.302/ 0.627 / 0.339 / 0.199 / 0.501respectively. The sex and the season of blood sampling were corrected by the method of advance. After correction, the OR value and 95 CI value of the second trimester interval were 0.459 / 0.3330.741and 0.4080.3170.3170.110.3870.2210.221 / 0.517 and the decrease of HSP risk respectively (P0.055.Conclusion the risk of HSP decreases with the increase of serum 25OHHHHHD level, which may be a protective factor for the pathogenesis of HSP. [WT5 "HZ] [WT5" HZ] [WT5BZ] there is a linear correlation between the increase of OR and the decrease of the risk of HSP.
【作者单位】：江西省赣州市人民医院/南昌大学附属赣州医院儿科;
【分类号】：R725.5

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