β受体阻滞剂治疗小儿扩张型心肌病的疗效观察

发布时间：2018-03-06 10:01

本文选题：心肌病　切入点：扩张型　出处：《重庆医学》2017年26期 　论文类型：期刊论文

【摘要】：目的观察β受体阻滞剂对小儿扩张型心肌病(DCM)的疗效。方法对1995年至2015年在该院住院的DCM患儿61例进行回顾性分析,根据是否服用β受体阻滞剂,将患儿分为治疗组(服用β受体阻滞剂,n=35)和对照组(未服用β受体阻滞剂,n=26),初步观察β受体阻滞剂的疗效。结果治疗后,治疗组心率、左心室舒张末期内径(LVDD)、左心室收缩末期内径(LVSD)、左心房内径(LA)较治疗前明显降低,射血分数(EF)明显升高(P0.05);对照组治疗后LVDD明显降低(P0.05),心率、右心室内径(RV)、LVDD、LVSD、LA、二尖瓣口血流速度(MV)及EF与入院前比较无明显变化(P0.05)。治疗后,治疗组心率、LVDD、LVSD、EF与对照组比较差异有统计学意义(P0.05),治疗组心功能较对照组明显改善(P0.05)。治疗组中伴有高血压的患儿心功能改善程度明显好于血压正常患儿(P0.05)。治疗组中经卡维地洛治疗的患儿心功能改善程度明显好于美托洛尔治疗的患儿(P0.05)。结论β受体阻滞剂可用于小儿DCM的治疗,对伴有高血压的DCM患儿疗效更佳,其中卡维地洛比美托洛尔疗效更加优秀。
[Abstract]:Objective To observe the effect of beta blockers in children with dilated cardiomyopathy (DCM) patients. Methods from 1995 to 2015 in the hospital from 61 DCM patients were retrospectively analyzed, according to whether taking beta blockers, patients were divided into treatment group (beta blocker, n=35) and control group (not taking beta receptor blocker, n=26), preliminary observation on the effects of beta blockers. Results after treatment, the treatment group of heart rate, left ventricular end diastolic diameter (LVDD), left ventricular end systolic diameter (LVSD), left atrial diameter (LA) significantly reduced ejection fraction (EF) increased significantly (P0.05); the control group after treatment, LVDD decreased significantly (P0.05), heart rate, right ventricular diameter (RV), LVDD, LVSD, LA, mitral blood flow velocity (MV) and EF before admission, no significant difference (P0.05). After treatment, the treatment group of heart rate, LVDD, LVSD, there was significant difference between EF and the control group (P0.05) The treatment group, the heart function improved significantly compared with the control group (P0.05). Cardiac function in patients with hypertension associated with the treatment group improved significantly better than the normal blood pressure in children (P0.05). Heart function in children with treatment with carvedilol treatment group improved significantly better than metoprolol in the treatment of children (P0.05). Conclusion the beta receptor blocker for the treatment of DCM in children, the DCM children with hypertension curative effect is better than the effect of metoprolol, carvedilol is more excellent.

【作者单位】：第三军医大学新桥医院儿科;
【分类号】：R725.4

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