3岁以下喘息患儿肠道主要微生物变化研究

发布时间：2018-03-10 01:27

本文选题：喘息　切入点：肠道菌群　出处：《重庆医学》2017年10期 　论文类型：期刊论文

【摘要】：目的探讨3岁以下喘息患儿肠道主要微生物变化,分析病理机制。方法选取唐山妇幼保健院2013年10月至2015年4月诊治的3岁以下喘息患儿143例为观察组,同期健康体检儿童143例为对照组,均行肠道菌群检测、T淋巴细胞检测、炎症因子检测、细胞因子检测。结果观察组双歧杆菌、B/E值、CD4~+、CD8~+、CD4~+/CD8~+、转化生长因子-β1(TGF-β1)低于对照组(P0.05)。观察组大肠杆菌、白细胞介素(IL)-17、C反应蛋白、白细胞计数高于对照组(P0.05)。双歧杆菌、B/E值与CD4~+、CD8~+、CD4~+/CD8~+、TGF-β1呈明显正相关性。双歧杆菌、B/E值与IL-17、C反应蛋白、白细胞计数呈明显负相关性。大肠杆菌与CD4~+、CD8~+、CD4~+/CD8~+、TGF-β1呈明显负相关性。大肠杆菌与IL-17、C反应蛋白、白细胞计数呈明显正相关性。结论 3岁以下喘息患儿肠道菌群有改变,双歧杆菌减少,大肠杆菌增加,可能与免疫功能、炎症反应有关。
[Abstract]:Objective to investigate the changes of intestinal microorganism in children under 3 years of age and to analyze the pathological mechanism. Methods 143 children under 3 years of age who were diagnosed and treated by Tangshan Maternal and Child Health Hospital from October 2013 to April 2015 were selected as observation group. In the same period, 143 healthy children were taken as the control group. All of them were examined by intestinal microflora, inflammatory factors and cytokines. Results the B / E value of Bifidobacterium in the observation group was CD4 ~ + CD8 ~ / CD8 ~ / CD8 ~. TGF- 尾 1) of TGF- 尾 1 was lower than that of control group (P 0.05). The leukocyte count of the observed group was higher than that of the control group (P 0.05). There was a significant positive correlation between the B- E value of Bifidobacterium and CD4 ~ + CD8 ~ / CD8 ~ + TGF- 尾 _ 1, and the relationship between the B- E value of Bifidobacterium and the IL-17C reactive protein. There was a negative correlation between Escherichia coli and CD4 ~ / CD8 ~ + TGF- 尾 _ 1, and a positive correlation between E. coli and IL-17 C-reactive protein and white blood cell count. Conclusion there is a change in intestinal microflora in children under 3 years of age with wheezing. The decrease of Bifidobacterium and the increase of Escherichia coli may be related to immune function and inflammation.
【作者单位】：华北理工大学生命科学学院;华北理工大学公共卫生学院;唐山市妇幼保健院儿科;
【分类号】：R725.6

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