血浆白细胞抗原G、白细胞介素10水平在传染性单核细胞增多症诊断中的价值

发布时间：2018-03-10 19:41

本文选题：传染性单核细胞增多症　切入点：白细胞抗原G　出处：《山东医药》2017年40期 　论文类型：期刊论文

【摘要】：目的探讨血浆白细胞抗原G(HLA-G)及白细胞介素10(IL-10)水平诊断传染性单核细胞增多症的价值。方法选择62例传染性单核细胞增多症患儿为观察组,60例健康儿童为对照组。采用ELISA法检测两组血浆HLA-G、IL-10水平;采用直线相关分析法分析观察组血浆HLA-G与IL-10的相关性;绘制血浆HLA-G、IL-10水平及二者联合检测诊断传染性单核细胞增多症的受试者工作曲线(ROC曲线),比较其曲线下面积,计算血浆HLA-G、IL-10水平及二者联合检测诊断传染性单核细胞增多症的效能。结果观察组、对照组血浆HLA-G水平分别为(32.32±10.87)、(6.55±3.24)U/mL,IL-10水平分别为(94.17±15.52)、(13.31±7.66)pg/mL。观察组血浆HLA-G、IL-10水平均高于对照组(P均0.05)。直线相关分析结果显示,观察组血浆HLA-G水平与IL-10水平呈正相关(r=0.497,P0.05)。血浆HLA-G、血浆IL-10及二者联合检测诊断传染性单核细胞增多症的ROC曲线下面积分别为0.701、0.622、0.870。约登指数最大时血浆HLA-G、IL-10水平(截断值)分别为10.6 U/mL、25.7pg/mL,此时血浆HLA-G水平诊断传染性单核细胞增多症的灵敏度为0.665、特异度为0.703;血浆IL-10水平分别为0.626、0.612,二者联合检测分别为0.851、0.834。二者联合检测诊断传染性单核细胞增多症的ROC曲线下面积、灵敏度、特异度均高于HLA-G、IL-10单项检测(P均0.05)。结论血浆HLA-G、IL-10水平均可用于传染性单核细胞增多症的诊断;二者联合检测的诊断效能优于单项检测。
[Abstract]:Objective to investigate the diagnostic value of plasma leucocyte antigen (GG) and interleukin-10 (IL-10) levels in the diagnosis of infectious mononucleosis. Methods Sixty-two children with infectious mononucleosis were selected as control group (n = 60) and control group (n = 60). The levels of HLA-GML-10 in plasma of the two groups were detected by ELISA method. The correlation between plasma HLA-G and IL-10 was analyzed by linear correlation analysis, the plasma HLA-Gtin-IL-10 level was drawn and the operating curve of the two groups for the diagnosis of infectious mononucleosis was measured, and the area under the curve was compared. To calculate the plasma HLA-Gtin-10 level and the efficacy of the two methods in the diagnosis of infectious mononucleosis. The plasma levels of HLA-G in the control group were 32.32 卤10.87 渭 g / mL, 6.55 卤3.24 渭 g / mL-1, respectively. The plasma levels of HLA-GIL-10 in the observation group were significantly higher than those in the control group (P < 0.05), and the levels of IL-10 in the plasma of the control group were higher than those in the control group (P = 0.05), and the levels of IL-10 in the plasma of the control group were 94.17 卤15.52 卤15.52 卤7.66 g / mL, respectively. There was a positive correlation between plasma HLA-G level and IL-10 level in the observation group. The plasma HLA-Gand the area under the ROC curve of plasma IL-10 and their combined detection in the diagnosis of infectious mononucleosis were 0.701 ~ 0.62222 ~ 0.870, respectively. The plasma HLA-GG IL-10 level (truncation value) was the highest in the Yorden index. The sensitivity and specificity of plasma HLA-G level in diagnosis of infectious mononucleosis were 0.665 and 0.703, respectively, and the plasma IL-10 levels were 0.626 ~ 0.612 and 0.885 ~ 0.834, respectively. The area under the ROC curve, The sensitivity and specificity were higher than that of HLA-GG IL-10 single detection (P < 0.05). Conclusion the plasma HLA-GG IL-10 level can be used in the diagnosis of infectious mononucleosis, and the diagnostic efficacy of the combined detection is better than that of single detection.
【作者单位】：聊城市人民医院;聊城市东昌府人民医院;
【基金】：中国博士后科学基金面上项目(2013M531617)
【分类号】：R725.1

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