Rh系统新生儿溶血病与IgG抗体亚类的相关性研究

发布时间：2018-03-14 08:28

  本文选题：新生儿　切入点：Rh血型　出处：《中国输血杂志》2017年04期 　论文类型：期刊论文

【摘要】：目的探讨Rh系统新生儿溶血病(Rh-HDN)与IgG抗体亚类的相关性。方法对50例孕妇产前抗体鉴定为Rh系统同种抗体,患儿出生后抽静脉血做Rh血型、直接coombs试验、游离抗体试验、直抗IgG亚类检测,将抗-D存在时分为1组与其他抗体组比较血清胆红素值,将IgG1、3同时存时分为1组与IgG1或IgG3单独存在时比较血清胆红素值。结果 Rh血型系统5种抗原D、C、c、E、e的相应抗体均可以引起Rh-HDN,其中抗-D(34%)、抗-E(28%)是最常见的抗体,抗-D较其他Rh抗体引起的HDN严重。新生儿直接coombs试验≥2+,游离抗体试验W+-3+,直抗IgG亚类主要为IgG1(38%)或IgG1、3(48%),IgG1、3同时存在时较单种IgG引起的HDN严重,同时发现IgG2和IgG4也能通过胎盘,结合在红细胞上引起HDN。结论抗-D、抗-E是最常见的引起Rh-HDN的Rh抗体,抗-D引起的HDN较严重;引起HDN的IgG亚类主要为IgG1或IgG1、3,IgG1、3同时存在时引起的HDN较严重。
[Abstract]:Objective to investigate the correlation between Rh-HDN and IgG antibody subclass in neonatal hemolytic disease of Rh system. Methods 50 pregnant women with prenatal antibody were identified as Rh homologous antibody. The serum bilirubin level was measured by direct anti IgG subclass detection, and the serum bilirubin was compared with other antibody groups in the presence of anti D. The serum bilirubin level was compared with that of IgG1 or IgG3 alone. Results the corresponding antibodies of five antigens of Rh blood group can cause Rh-HDNs, among which anti-DN34B, anti-EN-28) are the most common antibodies. HDN caused by anti-D antibody was more serious than that caused by other Rh antibodies. Direct coombs test 鈮，

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