不同维持量枸橼酸咖啡因治疗早产儿呼吸暂停的效果比较

发布时间：2018-03-14 12:38

本文选题：枸橼酸咖啡因　切入点：婴儿　出处：《广东医学》2017年S1期 　论文类型：期刊论文

【摘要】：目的评价不同维持量枸橼酸咖啡因治疗早产儿原发性呼吸暂停(AOP)的疗效及不良反应。方法选取AOP者60例,随机分为3组治疗:低维持量枸橼酸咖啡因组[LD组:首剂20 mg/kg,维持量5 mg/(kg·d)]、高维持量枸橼酸咖啡因组[HD组:首剂20 mg/kg,维持量10 mg/(kg·d)]、氨茶碱组,疗程均至呼吸暂停消失1周。比较3组患儿AOP消失时纠正胎龄、总氧疗时间等指标,并评估药物不良反应。结果 HD组及LD组氧疗结束日龄明显早于氨茶碱组,箱内或头罩吸氧时间较氨茶碱组明显减少(P0.05);胎龄34周中,HD组氧疗结束日龄明显早于氨茶碱组(P0.05),LD组与氨茶碱组差异无统计学意义(P0.05);LD组与HD组各指标差异无统计学意义(P0.05)。结论两种维持量枸橼酸咖啡因对AOP均有治疗作用,优于氨茶碱;在胎龄34周患儿中,高维持量疗效较低维持量略好;未见明显咖啡因不良反应。
[Abstract]:Objective to evaluate the efficacy and side effects of caffeine citrate in the treatment of premature infants with primary apnea. Methods 60 cases of AOP were selected. They were randomly divided into three groups: low maintenance dose citrate caffeine group [LD group: first dose 20 mg / kg, maintenance dose 5 mg/(kg 路d], high maintenance dose citrate caffeine group [HD group: initial dose 20 mg / kg, maintenance dose 10 mg/(kg 路d], aminophylline group, aminophylline group. The duration of treatment was 1 week. The corrected gestational age and total oxygen therapy time when AOP disappeared were compared among the three groups, and the adverse drug reactions were evaluated. Results the end age of oxygen therapy in HD group and LD group was significantly earlier than that in aminophylline group. The oxygen inhalation time in the box or hood was significantly lower than that in the aminophylline group, and in 34 weeks of gestational age, the oxygen therapy in HD group was significantly earlier than that in aminophylline group (P 0.05) and aminophylline group (P 0.05). There was no significant difference in every index between HD group and HD group. Conclusion two maintenance doses of caffeine citrate have therapeutic effect on AOP. It was superior to aminophylline. In 34 weeks of gestational age, the therapeutic effect of high maintenance dose was slightly better than that of low maintenance dose, and no obvious side effect of caffeine was observed.
【作者单位】：汕头市中心医院新生儿科;
【分类号】：R722.6

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