血清、脑脊液神经功能及炎性指标检测在手足口病患者中的价值研究

发布时间：2018-03-15 01:04

本文选题：血清　切入点：脑脊液　出处：《中华医院感染学杂志》2017年02期 　论文类型：期刊论文

【摘要】：目的研究血清、脑脊液中神经功能及炎性指标检测在手足口病患者中的价值,为手足口病患者的诊断与治疗提供参考依据。方法选取2012年3月-2014年3月医院诊治的50例手足口病患者为观察组,50名同龄健康人员为对照组,然后将两组受试人员的血清、脑脊液神经功能及炎性指标进行比较,并比较观察组轻度、中度及重度手足口病患者的检测结果。结果观察组血清及脑脊液中神经功能指标NSE、S100B及GFAP水平分别为(12.21±1.45)μg/L、(0.24±0.05)μg/L、(5.14±0.41)ng/L及(11.20±1.23)μg/L、(0.42±0.06)μg/L、(4.21±0.30)ng/L,均高于对照组的(5.88±0.59)μg/L、(0.15±0.02)μg/L、(2.21±0.25)ng/L及(4.95±0.46)μg/L、(0.21±0.04)μg/L、(1.98±0.17)ng/L,血清及脑脊液炎性指标也均高于对照组,观察组轻度、中度及重度手足口病患者的检测结果也存在明显差异(P0.05)。结论血清、脑脊液中神经功能及炎性指标检测在手足口病患者中的价值较高,对于疾病的诊断及严重程度的了解均有积极的临床意义。
[Abstract]:Objective to study the value of nerve function and inflammatory markers in serum and cerebrospinal fluid (CSF) in patients with hand, foot and mouth disease (HFMD). Methods 50 patients with HFMD from March 2012 to March 2014 were selected as the control group and 50 healthy persons of the same age were selected as the control group. The cerebrospinal fluid nerve function and inflammatory indexes were compared, and the observation group was mild. Results the levels of NSES100B and GFAP in serum and cerebrospinal fluid in the observation group were 12.21 卤1.45) 渭 g / L 0.24 卤0.05) 渭 g / L respectively 5.14 卤0.41ng / L and 11.20 卤1.23 渭 g / L / L and 11.20 卤1.23 渭 g / L / L 0.42 卤0.06 渭 g / L respectively, which were significantly higher than those in the control group (5.88 卤0.59) 渭 g / L 0.15 卤0.02 渭 g / L and 4.95 卤0.46 渭 g / L / L and 4.95 卤0.044 卤0.95 卤0.46 渭 g / L / L respectively, respectively, and were also higher than those in the control group (P / L = 5.88 卤0.59) 渭 g / L = 0.15 卤0.02 渭 g / L and 4.95 卤0.46 渭 g / L / L respectively, and the levels of serum and cerebrospinal fluid were also higher than those of the control group (n = 5.88 卤0.59) 渭 g / L = 0.15 卤0.02 渭 g / L and 4.95 卤0.46 渭 g / L / L respectively. In the observation group, there was also significant difference in the detection results of mild, moderate and severe HFMD patients. Conclusion the detection of nerve function and inflammatory indexes in serum and cerebrospinal fluid is more valuable in HFMD patients. The diagnosis and understanding of the severity of the disease have positive clinical significance.
【作者单位】：新乡市中心医院儿科;
【基金】：河南省科技厅科技发展技计划(14A561129)
【分类号】：R725.1

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