铅中毒儿童学习障碍、血清IgE、IGF-1表达与血铅相关性分析

发布时间：2018-03-15 06:28

本文选题：铅中毒儿童　切入点：学习障碍　出处：《毒理学杂志》2017年05期 　论文类型：期刊论文

【摘要】：目的探讨铅中毒儿童学习障碍、血清免疫球蛋白IgE、胰岛素生长因子1(IGF-1)表达与血铅相关性。方法回顾性分析本院2015年1月~2016年1月收治91例铅中毒儿童资料,根据入院后静脉血检血铅水平分为低血铅(血铅100~200μg/L)组30例、中血铅(血铅200~450μg/L)组30例和高血铅(血铅450~700μg/L)组31例,选取同年龄段、体检和智测均正常健康儿童30例作为对照组。测定和比较4组儿童大脑P300潜伏期和波幅、学习技能量表(LAS)测试评分、血清IgE和IGF-1表达。对铅中毒儿童学习障碍、血清IgE、IGF-1表达与血铅分析相关性。结果前额区、中央区、左中央区、右中央区和顶区P300潜伏期呈现正常组轻度中毒组中度中毒组重度中毒组(P0.05),P300波幅呈现正常组轻度中毒组中度中毒组重度中毒组(P0.05)。各组学习技能评分和IGF-1表达呈现正常组轻度中毒组中度中毒组重度中毒组(P0.01),血清IgE和血铅表达呈现正常组轻度中毒组中度中毒组重度中毒组(P0.01)。铅中毒儿童P300潜伏期、血清IgE与血铅水平呈正相关性(P0.05),铅中毒儿童P300波幅、学习技能评分、血清IGF-1与血铅水平呈负相关性(P0.01)。结论铅中毒患儿血铅表达与学习障碍越明显、血清IgE表达呈正相关,与IGF-1表达呈负相关。
[Abstract]:Objective to investigate the relationship between the expression of serum immunoglobulin IgE, insulin growth factor 1 IGF-1 and blood lead in children with lead poisoning. Methods the data of 91 children with lead poisoning from January 2015 to January 2016 were retrospectively analyzed. According to the blood lead levels of venous blood after admission, they were divided into three groups: low blood lead (100 渭 g / L), middle blood lead (200 ~ 450 渭 g / L) and high blood lead (450 渭 g / L) and high blood lead (450 ~ 700 渭 g / L). 30 healthy children with normal physical examination and intelligence test were used as control group. The P300 latency and amplitude of brain, learning skill scale (Lass) test score, serum IgE and IGF-1 expression were measured and compared in 4 groups. Results the expression of IGF-1 in serum was correlated with the analysis of blood lead. The latency of P300 in the right central and parietal regions showed that in the mild poisoning group, the moderate poisoning group, the severe poisoning group, the normal group, the mild poisoning group, the moderate poisoning group, the severe poisoning group, the normal group, the normal group, the mild poisoning group, the severe poisoning group, the learning skill score and the positive expression of IGF-1. The expression of serum IgE and blood lead in mild poisoning group, moderate poisoning group, severe poisoning group, normal group, mild poisoning group, severe poisoning group, P0. 01, P300 latent period of lead poisoning children, P0. 01, P0. 01, P0. 01, P0. 01, P0. 01, P0. 01, P0. 01. There was a positive correlation between serum IgE and blood lead level (P0.05). The amplitude of P300 wave, learning skill score, serum IGF-1 and blood lead level were negatively correlated with P0.01.Conclusion the more obvious the expression of blood lead and learning disorder, the more positive correlation is between the expression of serum lead and the expression of serum IgE in children with lead poisoning. There was a negative correlation with the expression of IGF-1.
【作者单位】：海南省妇幼保健院急诊儿科;东南大学附属第二医院急诊科;
【分类号】：R725.9

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