NICU早产儿医院感染相关危险因素的Meta分析

发布时间：2018-03-17 02:20

  本文选题：新生儿重症监护室　切入点：早产儿　出处：《浙江大学》2017年硕士论文　论文类型：学位论文

【摘要】：研究目的:对新生儿重症监护室(Neonatal Intensive Care Unit,NICU)早产儿医院感染相关危险因素进行Meta分析,为NICU早产儿医院感染的预防控制提供理论支持和指导意见。研究方法:在线检索中外文数据库Cochrane library、PubMed、中国生物医学文献数据库(CBM)、万方数据库、维普数据库、中国知网(CNKI),采用顺查法、倒查法、文献追溯的方法尽可能获得相关的参考文献,全面搜集国内外有关于NICU早产儿发生医院感染相关危险因素的原始文献,采用主题词、自由词相结合的检索策略进行检索,检索语种仅限于中文和英文。筛选出符合评价标准的文献,使用Review Manager 5.3软件对纳入的文献进行Meta分析,对计算结果采用固定效应模型和随机效应模型做敏感性分析,异质性较大的研究运用STATA软件对相关危险因素逐一进行Meta回归分析。研究结果:本研究共纳入8项研究,6个相关因素进行Meta分析,评估相关危险因素比值比及95%可信区间,分别为:体质量≤2500g OR=2.71,95%CI1.59～4.59;机械通气 OR=2.66,95%CI1.39～5.11;中心静脉留置 OR=6.91,95%CI3.87～12.35;全胃肠外营养 OR=2.45,95%CI 1.06～5.68;胃管留置 OR=3.22,95%CI(1.08～9.61);预防用抗菌药物OR=2.57,95%CI(0.84～7.80)无明显统计学意义,其他各研究间差异存在统计学意义。Meta回归分析结果分析显示最终纳入回归中的变量是地域,提示地域可能解释一部分异质性原因。结论:Meta分析表明低体质量、机械通气、胃管留置、全胃肠外营养、中心静脉留置使NICU早产儿更易发生医院感染。预防用抗菌药物不是早产儿NI的危险因素。
[Abstract]:Objective: to analyze the risk factors of nosocomial infection in Neonatal Intensive Care unit by Meta. To provide theoretical support and guidance for the prevention and control of nosocomial infection in premature infants of NICU. Methods: online retrieval of Chinese and foreign language database Cochrane librarybrium PubMed, Chinese biomedical literature database (CBM), Wanfang database, Weip database, etc. CNKI, with the methods of sequential, backward and retrospective, obtained as many references as possible, collected all the original literature at home and abroad on the risk factors of nosocomial infection in premature infants with NICU, and adopted the theme words. The retrieval strategy combined with free words is only limited to Chinese and English. The literature that meets the evaluation criteria is screened. The Meta analysis of the included documents is carried out by using Review Manager 5.3 software. The fixed effect model and the random effect model are used to analyze the sensitivity of the calculation results. STATA software was used to analyze the risk factors one by one by Meta regression analysis. Results: this study included 8 studies, 6 related factors were analyzed by Meta, the ratio of related risk factors and the 95% confidence interval were evaluated. They were: body weight 鈮，

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