不同年龄段儿童原发性EB病毒感染发病的临床特点

发布时间：2018-03-17 12:17

本文选题：原发性EB病毒感染　切入点：小儿　出处：《实用医学杂志》2017年09期 　论文类型：期刊论文

【摘要】：目的:探讨不同年龄段儿童原发性EB病毒感染(EBI)发病的临床特点。方法:回顾性分析330例住院患儿的临床资料,分为婴儿、幼儿、学龄前期、学龄期4组。结果:婴儿组24例(7.27%)、幼儿组172例(52.12%)、学龄前期组88例(26.67%)、学龄期组46例(13.94%)。季节分布幼儿组秋季高发,其余各组春季高发。各年龄段临床表现中均以传染性单核细胞增多症(IM)发生率最高(43.6%),呼吸道感染(41.2%)次之,其中婴儿组咳嗽、皮疹发生率最高(P0.05),学龄前期组肝脾大发生率最高,分别为68.2%、59.1%;检验方面血CD4+/CD8+随着年龄增加逐渐降低(P0.05),婴儿组肝损最大ALT(241±101.85)IU/L,婴儿组血清EBV-DNA阳性率为87%,EBV-CA-Ig M阳性率为13%,相差最大。结论:不同年龄组EBI在发病高峰、季节分布、临床表现、检验方面不完全相同,血清EBV-DNA有助于早期诊断。
[Abstract]:Objective: to investigate the clinical characteristics of primary EB virus infection (EBI) in children of different ages. Methods: the clinical data of 330 hospitalized children were analyzed retrospectively. Results: 24 cases in infant group, 172 cases in infant group, 82 cases in preschool group, 88 cases in preschool group, 46 cases in school age group and 46 cases in school age group were found to have a high incidence in autumn, while 24 cases in infant group, 172 cases in infant group, 88 cases in preschool group and 46 cases in school age group respectively. The incidence of infectious mononucleosis (IMD) was the highest in each age group, and the incidence of respiratory tract infection was 41.2%. The infant group had the highest incidence of cough and rash (P0.05), and the pre-school group had the highest incidence of liver and spleen enlargement. The blood CD4 / CD8 ratio decreased gradually with the increase of age, the largest ALT(241 卤101.85 ALT(241 / L in the infantile group, and the positive rate of serum EBV-DNA in the infant group was 87.EBV-CA-Ig M, the difference was the greatest. Conclusion: the incidence peak, seasonal distribution and clinical manifestation of EBI in different age groups. The test was not identical, and serum EBV-DNA was helpful for early diagnosis.
【作者单位】：南京医科大学附属儿童医院感染科;
【分类号】：R725.1

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