川崎病急性期患儿心电图QTc离散度对心肌损伤的诊断价值

发布时间：2018-03-23 12:10

本文选题：皮肤黏膜淋巴结综合征　切入点：川崎病　出处：《山东医药》2017年33期

【摘要】：目的探讨川崎病急性期患儿QTc离散度(QTcd)在心肌损伤中的意义及其与C反应蛋白(CRP)、血沉(ESR)的关系。方法选取川崎病(KD)急性期患儿68例(KD组),根据有无冠状动脉损伤(CALs)分为无CALs组53例和CALs组15例;选择56例健康体检儿童作为对照组。测定对照组及KD组急性期血液CRP、ESR及心肌肌钙蛋白I(c Tn I)水平,常规12导联心电图测量QTcd,分析QTcd与CRP、ESR及c Tn I的相关性。结果KD组QTcd、CRP、ESR及c Tn I均高于对照组(P均0.05)。CALs组患儿CRP及ESR水平高于无CALs组(P均0.05),QTcd及c Tn I在两组间未见统计学差异(P均0.05)。KD患儿QTcd与血液CRP、ESR及c Tn I水平呈正相关(r分别为0.51、0.55、0.57,P均0.05)。结论 KD患儿急性期心电图QTcd升高,可提示心肌炎症损伤和心肌炎的发生。
[Abstract]:Objective to investigate the significance of QTc dispersion in acute Kawasaki disease (Kawasaki disease) in myocardial injury and its relationship with C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Methods 68 children with Kawasaki disease in acute phase were selected as KD group, according to coronary artery injury or not. CALs group (n = 53) and CALs group (n = 15). In this study, 56 healthy children were selected as control group, the levels of CRPN ESR and cardiac troponin I Tn I were measured in the control group and KD group in acute phase. Routine 12-lead electrocardiogram was used to measure QTcdand to analyze the correlation between QTcd and CRPNSR and c TnI. Results the levels of CRP and ESR in KD group were higher than those in control group (P < 0.05) and ESR level in 0.05).CALs group were higher than those in control group (P < 0.05). There was a positive correlation between QTcd and the levels of blood CRP QTcd and c TnI in pediatric patients with 0.05).KD, and the positive correlation r was 0. 51 卤0. 555 and 0. 57P, respectively. Conclusion the QTcd of electrocardiogram is increased in children with KD in acute phase. May suggest myocardial inflammation injury and the occurrence of myocarditis.
【作者单位】：苏州大学附属第三医院常州市第一人民医院;
【基金】：常州市科技局应用基础研究(CJ2016003) 常州市卫计委重大课题(ZD201407)
【分类号】：R725.4

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