拉氧头孢钠注射剂联合甲硝唑片治疗肠无神经节细胞症患儿的临床研究

发布时间：2018-03-25 16:39

本文选题：拉氧头孢钠注射剂　切入点：甲硝唑片　出处：《中国临床药理学杂志》2017年23期

【摘要】：目的观察拉氧头孢钠注射剂联合甲硝唑片治疗肠无神经节细胞症的临床疗效及安全性。方法将90例肠无神经节细胞症患儿随机分为对照组和试验组,每组45例。所有患儿均在腹腔镜辅助下实施经肛门巨结肠根治术治疗。术后,对照组每次给予甲硝唑0.4 g,tid,口服;试验组在对照组治疗的基础上,给予拉氧头孢钠2.0 g,静脉滴注,qd。2组患儿均治疗21 d。比较2组患儿的临床疗效和药物不良反应发生情况。结果治疗后,试验组和对照组的总有效率分别为93.33%(42例/45例)和80.00%(36例/45例),差异有统计学意义(P0.05)。试验组的药物不良反应主要有小肠结肠炎、便秘、尿潴留,药物不良反应发生率为8.89%(4例/45例);对照组的药物不良反应主要有小肠结肠炎、直肠肌鞘夹层感染、便秘、尿潴留,药物不良反应发生率为31.11%(14例/45例),差异有统计学意义(P0.05)。结论拉氧头孢钠注射剂联合甲硝唑片可以提高肠无神经节细胞症患儿的治疗效果,降低药物不良反应的发生率。
[Abstract]:Objective to observe the clinical efficacy and safety of salicosporin injection combined with metronidazole tablet in the treatment of intestinal apogoneurosis. Methods 90 children with intestinal apogoneurosis were randomly divided into two groups: control group and experimental group. 45 cases in each group. All the children were treated with transanal megacolon radical operation under laparoscope. After operation, the control group was given metronidazole 0.4 g tid each time, and the experimental group was treated on the basis of the control group. The clinical efficacy and adverse drug reaction of the two groups were compared after treatment for 21 days. Results after the treatment, the clinical efficacy and adverse drug reactions of the two groups were compared. The total effective rates of the trial group and the control group were 93.33 and 86 / 45, respectively. The difference was statistically significant (P 0.05). The main adverse drug reactions in the test group were enterocolitis, constipation, and urinary retention. The incidence of adverse drug reactions was 8.89% and 45 cases respectively. In the control group, the main adverse drug reactions were enterocolitis, rectal muscle sheath infection, constipation, urinary retention. The incidence of adverse drug reactions was 31.1111 / 45. The difference was statistically significant (P0.050.Conclusion Loxocefose-sodium injection combined with metronidazole tablet can improve the therapeutic effect and reduce the incidence of adverse drug reactions in children with intestinal apogoneurosis.
【作者单位】：重庆医科大学附属儿童医院胃肠新生儿外科儿童发育疾病研究教育部重点实验室儿科学重庆市重点实验室重庆市儿童发育重大疾病诊治与预防国际科技合作基地;
【基金】：国家自然科学基金资助项目(81200258)
【分类号】：R725.7

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