加味二陈汤与抗生素序贯治疗小儿肺炎（痰湿阻肺型）的临床疗效

发布时间：2018-03-28 18:04

本文选题：小儿肺炎　切入点：痰湿阻肺型　出处：《山东中医药大学》2012年硕士论文

【摘要】：目的：研究加味二陈汤与抗生素序贯治疗小儿肺炎（痰湿阻肺型）的临床疗效方法：对山东中医药大学第二附属医院2011年10月至2012年3月收治的住院患儿进行研究。将符合病例纳入标准的早期细菌性肺炎（痰湿阻肺型）患儿给予常规抗生素治疗5天后随机分成治疗组、对照组，治疗组改为给予加味二陈汤治疗，对照组继续给予抗生素治疗。观察比较两组患儿的病情变化，观察时间为3天，观察项目包括咳嗽、肺内痰鸣音、肺内中小水泡音、舌苔、食欲、精神反应、白细胞、C反应蛋白、治疗费用等。采用资料完整的病例进行统计，将统计结果用SPSS16.0统计软件统计各组的均数、标准差，进行t检验，P0.05为两组间差异有统计学意义。结果：80例住院患儿，序贯治疗第1天治疗组与对照组咳嗽、肺内痰鸣音、肺内中小水泡音评分的比较没有显著差异（P均大于0.05）；序贯治疗第2、3天治疗组咳嗽、肺内痰鸣音、肺内中小水泡音评分均值明显低于对照组，两组的差异有统计学意义（P均小于0.05）。治疗后治疗组舌苔、食欲、精神反应情况评分均值明显低于对照组，两组的差异有显著统计学意义（P均小于0.05）。治疗前两组患儿白细胞均值高于正常值，且两组的差异无统计学意义（P0.05），治疗后，两组患儿白细胞均值均降低，两组的的差异无统计学意义（P0.05）。治疗前两组患儿CRP均值稍高于正常值，且两组的差异无统计学意义（P0.05）；治疗后，两组患儿CRP的均值均降低，两组的差异无统计学意义（P0.05）。治疗过程治疗组出现的副作用较少。治疗组患儿与对照组患儿总花费均值比较没有显著差异（P0.05），治疗组后3天治疗费用均值明显低于对照组，两组的差异有统计学意义（P0.05）。结论：短疗程抗生素联合加味二陈汤序贯治疗小儿细菌性肺炎（痰湿阻肺型）的临床疗效明显优于全疗程抗生素治疗小儿细菌性肺炎（痰湿阻肺型）的临床疗效。
[Abstract]:Objective: to study the clinical effect of modified Erchen decoction and antibiotics in sequential treatment of pediatric pneumonia (phlegm dampness obstructing lung type). Methods: the hospitalized children admitted to the second affiliated Hospital of Shandong University of traditional Chinese Medicine from October 2011 to March 2012 were studied. Children with early bacterial pneumonia (phlegm dampness obstruction pulmonary type) who met the criteria were given routine resistance. After 5 days of treatment with biotin, they were randomly divided into treatment group, In the control group, the treatment group was treated with modified Erchen decoction, and the control group continued to be treated with antibiotics. The changes of the condition of the children in the two groups were observed and compared. The observation time was 3 days. The observation items included cough, phlegm in the lung, and small blisters in the lung. Tongue coating, appetite, mental reaction, leukocyte C reactive protein, cost of treatment, etc. The statistical results were counted by SPSS16.0 software. T test (P0.05) was statistically significant between the two groups. Results there was no significant difference in the scores of cough, phlegm and small blisters in lung between the treatment group and the control group on the 1st day after sequential treatment (P > 0.05), but there was no significant difference in cough and phlegm sound in the treatment group on the 23rd day after sequential treatment, and there was no significant difference in the score of phlegm and phlegm in the lung between the treatment group and the control group on the first day of sequential treatment. The mean score of small blisters in the lung was significantly lower than that in the control group, and the difference between the two groups was significant (P < 0.05). After treatment, the mean scores of tongue coating, appetite and mental reaction in the treatment group were significantly lower than those in the control group. The difference between the two groups was statistically significant (P < 0.05). Before treatment, the mean value of white blood cells in the two groups was higher than the normal value, and the difference between the two groups was not statistically significant (P 0.05). After treatment, the mean value of white blood cells in the two groups decreased. The difference between the two groups was not statistically significant (P 0.05). Before treatment, the mean value of CRP in the two groups was slightly higher than the normal value, and the difference between the two groups was not statistically significant (P 0.05). There was no significant difference between the two groups (P 0.05). The side effects in the treatment group were less. There was no significant difference in the mean total cost between the treatment group and the control group, and the average treatment cost in the treatment group was significantly lower than that in the control group at 3 days after treatment. The difference between the two groups was statistically significant (P 0.05). Conclusion: the clinical efficacy of short course antibiotics combined with modified Erchen decoction in treating bacterial pneumonia in children (phlegm dampness obstruction lung type) is obviously better than that in the whole course of antibiotic treatment of bacterial pneumonia in children (phlegm dampness obstructing lung type).
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R725.6

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