不同类型尿道下裂的危险因素分析

发布时间：2018-03-28 16:56

  本文选题：尿道下裂　切入点：危险因素　出处：《中华男科学杂志》2017年05期

【摘要】：目的:探讨不同类型尿道下裂发病的危险因素。方法:按照1:1配比的方法,选取2015年10月至2016年10月间在郑州大学第三附属医院出生或就诊的尿道下裂患儿和健康胎儿或非泌尿系统疾病患儿分别作为病例组和对照组,采用单因素分析和多因素Logistic回归分析的方法,分析总体和4种不同类型尿道下裂的危险因素。结果:共有440例样本被纳入研究。结果显示,总体尿道下裂的危险因素包括早产、胎儿生长受限、母亲居住地为农村、母亲怀孕年龄20岁或35岁、初产妇、孕期吸烟与被动吸烟、孕期服用孕激素、孕期有感冒及发热症状、孕早期高温暴露,保护因素为孕早期补充蛋白质。Ⅰ型尿道下裂的危险因素包括母亲怀孕年龄20岁或35岁,保护因素包括孕早期补充蛋白质。Ⅱ型尿道下裂的危险因素包括早产,胎儿生长受限,母亲居住地为农村,初产妇,孕期吸烟与被动吸烟,保护因素包括孕早期补充蛋白质。Ⅲ型尿道下裂的危险因素包括早产,胎儿生长受限,母亲居住地为农村,孕早期高温暴露,保护因素包括孕早期补充蛋白质。Ⅳ型尿道下裂的危险因素包括孕早期高温暴露,孕期服用孕激素。结论:不同类型尿道下裂的危险因素存在差异,临床研究和预防尿道下裂的发病应有针对性。后期仍需扩大样本量以对不同类型尿道下裂的危险因素进行更加科学稳定的研究。
[Abstract]:Objective: to investigate the risk factors of different types of hypospadias. From October 2015 to October 2016, children with hypospadias and healthy fetuses or non-urinary diseases were selected as the case group and the control group, respectively, who were born or treated in the third affiliated Hospital of Zhengzhou University. Single factor analysis and multivariate Logistic regression analysis were used to analyze the risk factors of total and 4 different types of hypospadias. Results: a total of 440 samples were included in the study. The results showed that the risk factors of total hypospadias included preterm labor. Fetal growth restriction, mother living in rural areas, pregnant age 20 or 35 years old, primipara, smoking and passive smoking during pregnancy, pregnancy with progesterone, pregnancy with cold and fever symptoms, early exposure to high temperature, The protective factors of type 鈪，

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