三维水选择性激励序列在儿童血友病性骨关节病软骨显示应用价值研究

发布时间：2018-03-28 22:07

本文选题：关节软骨　切入点：血友病　出处：《中国实用儿科杂志》2017年01期

【摘要】：目的采用定性及定量评价方法,探讨三维水选择性激励序列(3D T1W-WATS)在儿童血友病性骨关节病软骨显示中的价值。方法 2015年2月在首都医科大学附属北京儿童医院进行随诊复查并行磁共振(MR)检查的16例血友病患儿,对其16个关节包括8个膝关节和8个踝关节(13个关节有含铁血黄素沉积)在3T MR上行矢状位3D T1W-WATS序列和2D T2*W序列扫描,定量比较两个序列的软骨信噪比及软骨与周围组织的相对对比度,定性比较两个序列中部分或完全受含铁血黄素掩盖的软骨亚分区数目。信噪比及相对对比度计算公式为SNRcartilage=SI软骨/SD噪声,r CN=(SI软骨-SI周围组织)/(SI软骨+SI周围组织),13个含铁血黄素沉积关节的关节软骨被分成142个软骨亚分区。结果 3D T1W-WATS序列的软骨信噪比为(53.93±18.80),2D T2*序列的软骨信噪比为(52.96±24.32),两个序列间差异没有统计学意义(P0.05)。3D T1W-WATS序列的软骨与骨髓、软骨与积液及软骨与脂肪的相对对比度优于2D T2*W序列;在142个软骨亚分区中,2D T2*W序列中有42个亚分区软骨部分或完全地被含铁血黄素掩盖,明显多于3D T1W-WATS序列中的16个软骨亚分区,两个序列受含铁血黄素掩盖软骨亚分区数差异有统计学意义(P0.05)。结论 3D T1W-WATS序列具有高分辨率,高信噪比及优异的软骨对比度,而且软骨不易受含铁血黄素影响,对血友病性骨关节病软骨显示优于2D T2*W序列。
[Abstract]:Objective to adopt qualitative and quantitative evaluation methods, To explore the value of 3D T1W-WATS in displaying the cartilage of hemophilia osteoarthritis in children. Methods in February 2015, follow-up reexamination and MRN were performed at Beijing Children's Hospital affiliated to Capital Medical University. Of 16 children with hemophilia, Sixteen joints including 8 knee joints and 8 ankle joints (13 joints with hemosiderin deposition) were scanned with 3D T1W-WATS and 2D T2W sequences in the ascending sagittal position of 3T Mr. The signal-to-noise ratio (SNR) of cartilage and the relative contrast between cartilage and surrounding tissue were compared quantitatively. The number of cartilage subzones partially or completely masked by hemosiderin in the two sequences was qualitatively compared. The formula for calculating signal-to-noise ratio (SNR) and relative contrast is SNRcartilage=SI cartilage / SD noise / r CN=(SI cartilage / SI peri-SI tissue. The articular cartilage containing hemosiderin deposition joint was divided into 142 cartilage subzones. Results the cartilage signal-to-noise ratio (SNR) of 3D T1W-WATS sequence was 53.93 卤18.80 T2 * sequence (52.96 卤24.32). There was no significant difference in cartilage and bone marrow between the two sequences. The relative contrast of cartilage and effusion and cartilage to fat was better than 2D T2W sequence, 42 of 142 cartilage subzones were partially or completely covered by hemosiderin. The number of cartilage subzones of the two sequences masked by hemosiderin was significantly higher than that of 3D T1W-WATS sequences (P 0.05). Conclusion 3D T1W-WATS sequences have high resolution, high signal-to-noise ratio (SNR) and excellent cartilage contrast. Moreover, the cartilage is not easily affected by hemosiderin, which is superior to 2D T _ 2 W sequence in the display of hemophilic osteoarthritis cartilage.
【作者单位】：首都医科大学附属北京儿童医院;
【分类号】：R725.5

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