呼吸道过敏患儿与特异性IgG抗体表达水平的相关研究

发布时间：2018-03-30 09:40

  本文选题：特异性IgG　切入点：非IgE介导　出处：《中国现代医学杂志》2017年07期

【摘要】：目的探讨食物特异性IgG的表达水平与非IgE介导的呼吸道过敏的关系,以及特异性IgG定量检测能否作为食物引起呼吸道过敏反应的诊断指标之一。方法选取2013年12月-2015年12月在该院儿科哮喘门诊诊治的非IgE介导呼吸道过敏的患儿,共78例,健康对照组27例。在饮食回避后对入组患儿进行疗效判断,其标准为症状消失或明显改善,症状评分为3分;症状有所改善为2分;症状无改善或加重为1分视为无效。然后,对特异性IgG的表达水平与临床症状评分之间的关系进行分析,并通过ROC曲线评估特异性IgG的诊断价值。结果过敏组患儿的临床症状得分以及特异性IgG的表达水平,与对照组比较,均升高,差异有统计学意义(P0.05)。入组患儿的临床症状得分与特异性IgG水平呈正相关;且特异性IgG的诊断准确性较高,ROC曲线下面积为0.713。结论特异性IgG抗体水平的测定在非IgE介导儿童食物引起呼吸道过敏诊断中有一定的参考价值,可在临床上推广使用。
[Abstract]:Objective to investigate the relationship between the expression of food-specific IgG and non-#en1# induced respiratory allergies. Methods 78 children with non-#en1# induced respiratory hypersensitivity were selected from December 2013 to December 2015 in pediatric asthma clinic of our hospital, and whether the quantitative detection of specific IgG can be used as one of the diagnostic indexes of respiratory allergic reaction induced by food. 27 cases of healthy control group. After diet avoidance, the therapeutic effect of the children in the group was judged. The standard was that the symptoms disappeared or improved obviously, the symptom score was 3; the symptom improved to 2; the symptom did not improve or aggravated to 1 as invalid. Then, The relationship between the expression level of specific IgG and clinical symptom score was analyzed, and the diagnostic value of specific IgG was evaluated by ROC curve. Compared with the control group, all of them were increased, the difference was statistically significant (P 0.05). The clinical symptom scores of the children in the group were positively correlated with the level of specific IgG. The area under the curve of specific IgG is 0.713.Conclusion the determination of specific IgG antibody level has certain reference value in the diagnosis of non-#en2# induced respiratory allergy in children, and can be popularized in clinic.
【作者单位】： 上海市徐汇区大华医院儿科;上海市徐汇区大华医院检验科;
【基金】：上海市卫计委基金资助项目(No:20134250)
【分类号】：R725.6

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