儿童哮喘控制测试与肺功能的相关性研究

发布时间：2018-03-31 09:03

本文选题：哮喘　切入点：儿童哮喘控制测试　出处：《青岛大学》2017年硕士论文

【摘要】：目的:探讨不同年龄儿童哮喘控制测试(Childhood asthma control test,C-ACT)与肺通气功能的关系。方法:选取2015年5月-2016年5月在我院确诊并进行规范化治疗的支气管哮喘患儿164例,其中男99例,女65例;平均年龄(8.43±2.08)岁,将所有入选患儿根据年龄分为低年龄组(n=80):年龄为4-6岁,平均年龄为(5.28±0.39)岁;高年龄组(n=84):年龄为7-11岁,平均年龄(9.04±1.79)岁。观察治疗前、治疗后6个月哮喘患儿的C-ACT评分和肺功能相关指标(FEV1%、PEF%、MEF50%)的变化,探讨儿童哮喘控制测试与肺功能的相关性。结果:(1)治疗前,低年龄组哮喘患儿的C-ACT评分为15.7±2.41,FEV1%、PEF%和MEF50%分别为52.1±11.47、51.4±10.91和58.3±16.04;C-ACT评分与FEV1%、PEF%、和MEF50%的相关系数r分别为0.174、0.274和0.241,相对应的P值分别为0.061、0.151和0.121,P0.05,均没有显著性差异,无统计学意义。高年龄组哮喘患儿的C-ACT评分为15.6±2.44,FEV1%、PEF%、MEF50%分别为51.33±10.92、52.1±12.29和59.2±16.33;C-ACT评分与FEV1%、PEF%、MEF50%的相关系数r分别为0.341、0.392和0.412,相对应的P值分别为0.010、0.021和0.008,P0.05,存在显著的正相关,有统计学意义。(2)治疗后6个月,低年龄组哮喘患儿的C-ACT评分为22.3±2.39,FEV1%、PEF%、MEF50%分别为73.5±16.38、71.8±12.17和78.5±15.16;C-ACT评分与FEV1%、PEF%、MEF50%的相关系数r分别为0.183、0.263和0.250,对应的P值分别为0.082、0.141和0.132,P0.05,均没有显著性差异,无统计学意义。高年龄组哮喘患儿的C-ACT评分为22.8±2.54,FEV1%、PEF%、MEF50%分别为77.95±16.91、75.52±16.53和77.4±19.26;C-ACT评分与FEV1%、PEF%、MEF50%的相关系数r分别为0.352、0.402和0.432,相对应的P值分别为0.011、0.019、0.005,存在显著的正相关。C-ACT评分以及肺功能相关指标治疗前后均有显著性提高,差异具有统计学意义(P0.05)。结论:作为一种评估哮喘控制情况的方法,更适用于高年龄组(7-11岁)患儿。
[Abstract]:Objective: to investigate the relationship between childhood asthma control test C-ACTand pulmonary ventilation function in children of different ages. Methods: 164 children with bronchial asthma diagnosed and treated with standardized treatment from May 2015 to May 2016 were selected, including 99 males. There were 65 females with an average age of 8.43 卤2.08 years. All the children were divided into low age group (4-6 years old, mean age 5.28 卤0.39) and older group (7-11 years, mean age 9.04 卤1.79). After 6 months of treatment, the changes of C-ACT score and pulmonary function related index (FEV1 / PEF50) in children with asthma were investigated, and the correlation between the control test of asthma and pulmonary function was investigated. The C-ACT scores of PEF% and MEF50% were 52.1 卤11.47 卤51.4 卤10.91 and 58.3 卤16.04 卤16.04 and the correlation coefficients r were 0.1740.274 and 0.241, respectively. The corresponding P values were 0.061 卤0.151 and 0.121%, respectively, no significant difference was found between the scores of PEF% and FEV1-PEF5.There was no significant difference between the scores of PEF% and FEV1, and the correlation coefficients (r) of 50% and 50% of the scores were 0.1740.274 and 0.241, respectively, and the corresponding P values were 0.061 and 0.121, respectively. There was no statistical significance between the C-ACT score of 15. 6 卤2. 44 and FEV1 scores of 51.33 卤10. 92 卤52. 1 卤12. 29 and 59.2 卤16. 33% of the patients with asthma and the correlation coefficient r of 50% of FEV1 PEFI with FEV1 + PEF0. 392 and 0.412, respectively. The corresponding P values were 0. 010. 021 and 0. 008? P5, respectively. There was a significant positive correlation between the scores, and the correlation coefficients were 0. 341 and 0. 412, respectively, and the corresponding P values were 0. 010. 021 and 0. 008? P5, respectively. After 6 months of treatment, the C-ACT scores of low age children with asthma were 22.3 卤2.39 FEV1 and 73.5 卤16.38%, 73.5 卤16.38 卤71.8 卤12.17 and 78.5 卤15.16, respectively. The correlation coefficient r between the scores of C-ACT and FEV1 were 0.183 卤0.263 and 0.250, respectively, and the corresponding P values were 0.082 0.141 and 0.132 P 0.05, respectively. There was no statistical significance. The C-ACT scores of children with asthma were 22.8 卤2.54FEV1and PEF50% were 77.95 卤16.91g 75.52 卤16.53,77.4 卤19.26m C-ACT and the correlation coefficient r of FEV1PEFU MEF50% were 0.3520.402 and 0.432respectively, and the corresponding P values were 0.0110.0190.005, respectively. There was significant positive correlation between C-ACT score and pulmonary function phase score (P = 0.0110.0190.005). Before and after treatment, there was a significant increase in the index of Guan, Conclusion: as a method to evaluate the control of asthma, it is more suitable for children aged 7-11 years.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R725.6

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