铁代谢与新生儿缺氧缺血性脑损伤

发布时间：2018-03-31 12:42

本文选题：铁代谢　切入点：缺氧缺血性脑损伤　出处：《生理学报》2017年02期

【摘要】：铁是神经系统正常发育必不可少的金属元素,受多种因素的调节。近年来的研究表明,铁代谢改变是新生儿缺氧缺血性脑损伤(hypoxic ischemic brain damage,HIBD)重要的发病机制之一,也是造成新生儿HIBD后永久性神经伤残的重要原因。缺氧缺血后机体铁循环发生改变,并随着病程的发展引发脑内铁代谢紊乱,脑内铁蓄积,后经多种途径参与脑内神经细胞的损伤过程。因此,研究缺氧缺血如何造成机体循环铁与脑内铁代谢的改变以及两者间可能存在的联系,阐明铁代谢紊乱在HIBD发生和发展中的机制,将为HIBD的预防和治疗提供依据。本文综述了HIBD发病过程中铁代谢变化及其影响因素,以及铁代谢紊乱如何参与HIBD的发生和发展。
[Abstract]:Iron is an essential metal element in the normal development of nervous system, which is regulated by many factors. Recent studies have shown that iron metabolism is one of the important pathogenesis of hypoxic ischemic brain damage in neonates. It is also an important cause of permanent neurological disability after HIBD. After hypoxic ischemia, iron circulation changes in the body, and with the development of the course of disease, the iron metabolism in the brain is disturbed and the iron accumulates in the brain. Therefore, to study how hypoxia-ischemia results in the changes of circulating iron and iron metabolism in brain and the possible relationship between them. To clarify the mechanism of iron metabolism disorder in the occurrence and development of HIBD will provide the basis for the prevention and treatment of HIBD. This article reviews the changes of iron metabolism and its influencing factors during the pathogenesis of HIBD, and how iron metabolism disorder participates in the occurrence and development of HIBD.
【作者单位】：中国科学院昆明动物研究所中国科学院/云南省动物模型与人类疾病机理重点实验室;昆明医科大学基础医学院病理与病理生理学系;中国科学院大学;
【基金】：国家自然科学基金项目(No.81200939、31260242) 云南省自然科学基金项目(No.2011FB060)
【分类号】：R742

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