益生菌在新生儿坏死性小肠结肠炎中的应用

发布时间：2018-04-02 14:18

本文选题：益生菌　切入点：早产儿　出处：《中国实用儿科杂志》2017年02期

【摘要】：新生儿坏死性小肠结肠炎(NEC)是新生儿期常见的严重胃肠道急症,以往研究认为,早产、感染、配方奶喂养、缺血缺氧是引发NEC的重要因素。近年来大量研究表明,肠道菌群失衡是引发NEC的重要和基础原因,新生儿生后肠道获取健康的共生菌,可以阻断因肠道正常菌群缺失或异常的菌群定植过程,使未成熟肠道免于炎症或损伤,这是降低NEC发生风险的关键因素。提供益生菌可维护肠道菌群平衡,使致病型微生态模式转换至保护型健康的微生态模式,防御肠道的炎症损害,预防NEC发生。此篇文章阐述了早产儿NEC与肠道菌群的关系,阐明了益生菌制剂防治NEC的作用机制、临床疗效和安全性。
[Abstract]:Neonatal necrotizing enterocolitis (NEC) is a common severe gastrointestinal emergency in neonatal stage. Previous studies have suggested that premature delivery infection formula feeding ischemia and hypoxia are important factors causing NEC.In recent years, a large number of studies have shown that the imbalance of intestinal flora is an important and basic cause of NEC. The healthy symbiotic bacteria obtained from the intestinal tract of newborn infants can block the process of colonization due to the absence or abnormality of normal intestinal flora.Keeping immature intestines free from inflammation or damage is a key factor in reducing the risk of NEC.The probiotics can maintain the balance of intestinal flora, change the pathogenic microecological model to the protective microecological model, protect the intestinal inflammatory damage and prevent the occurrence of NEC.This article describes the relationship between NEC and intestinal flora in premature infants, and illustrates the mechanism, clinical efficacy and safety of probiotics in preventing and treating NEC.
【作者单位】：河北医科大学第三医院儿科;
【分类号】：R722.1

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