TLR7基因rs3853839、rs179010多态性与EV71手足口病男性患儿易感性及病情严重程度相关

发布时间：2018-04-04 05:10

本文选题：肠道病毒型　切入点：Toll样受体(TLR)　出处：《细胞与分子免疫学杂志》2017年07期

【摘要】：目的探讨Toll样受体7/髓样分化因子88(TLR7/My D88)信号通路基因多态性与肠道病毒71型(EV71)手足口病(HFMD)易感性及重症化的关联性。方法收集在西安交通大学第二附属医院和西安市儿童医院感染科收治的EV71 HFMD标本180例和健康对照标本201例。采用SNPscan多重SNP分型方法对381个样本的TLR7基因rs3853839、rs179010和My D88基因rs7744位点进行基因分型检测。结果男性患儿中TLR7基因rs3853839 C等位基因的易感性(OR=2.343,95%CI:1.516~3.621)与重症化(OR=1.939,95%CI:1.064~3.521)风险升高。男性患儿中TLR7rs179010 T等位基因的易感性(OR=1.701,95%CI:1.142~2.535)与重症化(OR=1.852,95%CI:1.038~3.305)风险升高。女性患儿中TLR7基因rs3853839、rs179010等位基因分布在病例组与对照组无明显差异。My D88基因rs7744多态性与EV71 HFMD易感性及病情轻重程度无明显关联性。结论 TLR7基因rs3853839、rs179010多态性与EV71 HFMD男性患儿易感性及病情严重程度相关。
[Abstract]:Objective to investigate the association of Toll like receptor 7 / myeloid differentiation factor 88(TLR7/My D88 gene polymorphism with susceptibility and severity of enterovirus 71 (EV71) hand, foot and mouth disease (HFMD).Methods 180 EV71 HFMD specimens and 201 healthy controls were collected from the second affiliated Hospital of Xi'an Jiaotong University and Department of Children's Hospital infection of Xi'an City.The rs3853839 rs179010 and my D88 rs7744 loci of TLR7 gene in 381 samples were detected by SNPscan multiplex SNP typing method.Results in male children, the susceptibility of rs3853839 C allele of TLR7 gene was 2.343N95% CI: 1.516 + 3.621) and the risk was increased by 1.939% 95% CI: 1.064 + 3.521).The risk of susceptibility to TLR7rs179010 T allele in male children was increased by 1. 701: 95 CI: 1. 142 + 2. 535) and 1. 852 / 95 CI: 1.03838 / 3.305).There was no significant difference in the distribution of rs3853839 / rs179010 allele in female children between the case group and the control group. There was no significant correlation between the rs7744 polymorphism of my D88 gene and the susceptibility to EV71 HFMD and the severity of the disease.Conclusion the rs3853839 rs179010 polymorphism of TLR7 gene is associated with the susceptibility and severity of EV71 HFMD in male children.
【作者单位】：西安交通大学第二附属医院感染科;西安市儿童医院感染科;
【基金】：国家自然科学基金(81500453)
【分类号】：R725.1

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