噬血细胞综合征临床特点与预后因素研究

发布时间：2018-04-09 01:00

本文选题：噬血细胞综合征　切入点：临床特点　出处：《重庆医学》2017年07期

【摘要】：目的探讨噬血细胞综合征(HPS)的临床特点以及预后因素。方法选择该院收治的HPS患儿62例,对患儿的临床资料及实验室检查结果进行回归性研究。结果 62例患儿中,好转或痊愈62.90%(39/62),病死37.10%(23/62)。其中,原发性HPS患儿好转或痊愈为26.32%,病死率为73.68%,继发性HPS患儿好转或痊愈为79.07%,死亡率为20.93%,两组比较差异有统计学意义(P0.05);与好转或痊愈患儿比较,死亡组年龄、肝肿大、脾肿大、白细胞计数(WBC)、血小板计数(PLT)、纤维蛋白原(Fig)、乳酸脱氢酶(LDH)、丙氨酸转氨酶(ALT)水平差异有统计学意义(P0.05)。结论 HPS的病因复杂,且预后多不佳;其年龄、肝肿大、脾肿大、WBC、PLT、Fig、LDH及ALT等水平能够作为临床预测HPS患儿预后的重要指标。
[Abstract]:Objective to investigate the clinical features and prognostic factors of hemophagocytic syndrome (HPS).Methods 62 cases of HPS in our hospital were selected and the clinical data and laboratory results were studied by regression analysis.Results among the 62 cases, 62.90% were improved or cured, and 37.10% died of disease.Among them, the improvement or recovery of primary HPS was 26.32, the mortality was 73.68, the secondary HPS was 79.07 and the mortality was 20.93.The difference between the two groups was statistically significant (P 0.05), and the age, hepatomegaly and splenomegaly in the death group were significantly higher than those in the improved or cured children, and there was no significant difference between the two groups in age, hepatomegaly and splenomegaly.There were significant differences in WBC count, platelet count and PLT, fibrinogen, lactate dehydrogenase (LDH) and alanine aminotransferase (alt) levels in WBC, PLT, fibrinogen, lactate dehydrogenase (LDH) and alanine aminotransferase (alt).Conclusion the etiology of HPS is complicated and the prognosis is not good, and its age, hepatomegaly, splenomegaly, LDH and ALT can be used as important indexes to predict the prognosis of HPS children.
【作者单位】：郑州大学第一附属医院血液科;
【分类号】：R725.5

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