诺如病毒Ⅱ型感染儿童的肠道排毒时间及其相关因素的研究

发布时间：2018-04-14 12:07

本文选题：诺如病毒 + 排毒时间　；参考：《现代预防医学》2017年20期

【摘要】：目的对诺如病毒Ⅱ型(GⅡ型)感染儿童的肠道排毒时间及其相关因素进行探讨,为诺如病毒的防控提供科学依据。方法对急性胃肠炎暴发疫情中经实时荧光定量反转录聚合酶链反应确诊为GII型阳性的51名儿童进行连续8周的随访和采样工作,收集研究对象的基本资料、临床表现以及诊疗情况,每隔7 d采集1次肛拭子进行核酸检测。利用生存分析的方法对资料进行分析。结果随访期所有对象第一周的排毒率高达62.75%,平均排毒时间为11.37 d,最长排毒时间为52 d。所有对象在第3 d、10 d、17 d、24 d、31 d和52 d的排毒率依次为62.75%、31.37%、13.73%、5.88%、1.96%和0,对男童和女童的排毒率、病例儿童和无症状的隐性感染儿童的排毒率分别进行Log-rank检验,差异均无统计学意义。感染儿童排毒的病毒载量随着时间的增加而下降(F=11.31,P=0.023)。Cox回归的结果显示就诊组的排毒时间短于未就诊组(HR=1.83,P=0.041)。结论病例儿童和隐性感染儿童之间的排毒时间无统计学差异,提示隐性感染儿童在诺如病毒传播过程中所起的作用不容忽视。去医院就诊使用药物后可能会缩短儿童的排毒时间。
[Abstract]:The purpose of norovirus type II (G II) were discussed and the related factors of the infection of intestinal detoxification time children, provide scientific basis for the prevention and control of norovirus. Methods the acute gastroenteritis outbreaks by real-time fluorescent quantitative reverse transcription polymerase chain reaction was diagnosed in 51 children with type GII positive for 8 consecutive weeks of follow-up and the sampling work in the epidemic, collected the basic information of the research object, clinical manifestations, diagnosis and treatment, every 7 d acquisition 1 rectal swabs were detected. The data was analyzed by the method of survival analysis. Results the follow-up of all objects the first week detoxification rate as high as 62.75%, the average drainage time is 11.37 d the longest time is 52 D. detoxification of all objects in the third D, 10 d, 17 D, 24 D, 31 D and 52 D, the detoxification rate was 62.75%, 31.37%, 13.73%, 5.88%, 1.96% and 0 for boys and girls, detoxification rate, and asymptomatic cases of children Log-rank test was used for the detoxification rate of latent infection in children, the difference was not statistically significant. Infected children detoxification virus load decreased with the increase of time (F=11.31, P=0.023).Cox regression showed that treatment group of detoxification in a short time without visiting a group (HR=1.83, P= 0.041). Conclusion the cases of children and the recessive infection in children there was no significant difference between detoxification time, suggesting that the recessive infection children can not be ignored in the norovirus spreading process in the role. Go to the hospital after the use of drugs may reduce children's detoxification time.

【作者单位】：江阴市疾病预防控制中心;江苏省现场流行病学培训项目;常州市疾病预防控制中心;常州市武进区疾病预防控制中心;无锡市疾病预防控制中心;
【基金】：江苏省预防医学科研项目(Y2015006)
【分类号】：R725.1

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