不同吸入麻醉药全麻对小儿法洛四联症术后肝肾功能影响

发布时间：2018-04-15 12:39

本文选题：异氟醚 + 七氟醚　；参考：《江西医药》2013年07期

【摘要】：目的探讨不同吸入麻醉药全麻对小儿法洛四联症(TOF)术后肝肾功能影响。方法将48例TOF患儿随机均分为3组。对照组患儿在术前全凭静脉用药进行全麻;七氟醚组患儿在静脉用药的基础上,吸入七氟醚进行全麻;异氟醚组患儿在静脉用药的基础上,吸入异氟醚进行全麻。分别在术前和术后48h抽取3组患儿的血液和新鲜尿液样本,进行肝肾功能指标检测。结果3组患儿术前肝肾功能指标无显著性差异;术后48h七氟醚组AST、BUN、Cr和尿NAG/Cr水平较对照组有明显的降低(P0.05)。结论全麻体外循环心脏手术治疗小儿法洛四联症后,对患儿肝肾都造成损害;七氟醚或异氟醚进行吸入麻醉后进行手术,术后患儿肝功能指标基本一致;麻醉术后肾功能结果显示,相对于异氟醚,七氟醚可降低术后患儿肾功能的损害程度。
[Abstract]:Objective to investigate the effect of general anesthesia with different inhaled anesthetics on liver and kidney function in children with tetralogy of Fallot.Methods 48 children with TOF were randomly divided into 3 groups.Patients in the control group received general anesthesia by intravenous administration before operation; sevoflurane group inhaled sevoflurane for general anesthesia on the basis of intravenous medication; isoflurane group inhaled isoflurane for general anesthesia on the basis of intravenous medication.Blood and fresh urine samples were collected before and 48 hours after operation to detect liver and kidney function.Results there was no significant difference in preoperative liver and kidney function among the three groups, and the levels of bun Cr and urinary NAG/Cr in the sevoflurane group were significantly lower than those in the control group at 48 h after operation (P 0.05).Conclusion after general anesthesia cardiopulmonary bypass heart surgery for tetralogy of Fallot in children, the liver and kidney were damaged, sevoflurane or isoflurane were operated on after inhalation anesthesia, the liver function indexes were basically the same after operation.The results of renal function after anesthesia showed that sevoflurane could decrease the degree of renal function impairment in children after operation compared with isoflurane.
【作者单位】：江西省九江市171医院;
【分类号】：R726.1

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