贵州省2008-2015年手足口病病原学监测分析

发布时间：2018-04-16 10:19

本文选题：手足口病 + 肠道病毒　；参考：《中国疫苗和免疫》2017年04期

【摘要】：目的了解贵州省2008-2015年手足口病(Hand,foot and mouth disease,HFMD)病原谱构成和分布特征,为HFMD预防控制提供参考。方法收集贵州省各市(州)采集的HFMD病例标本和临床信息,并采用Real time-PCR检测肠道病毒(EV)感染状况,进行描述性分析。结果 2008-2015年共收集和检测30 069份HFMD病例标本,其中EV阳性16 122份(53.62%)。在EV阳性标本中,肠道病毒A71型(EV-A71)阳性5 004份(31.04%),柯萨奇病毒A16型(CV-A16)阳性3 532份(21.91%),EV-A71和CV-A16均阳性145份(0.90%),其他EV阳性7 441份(46.15%)。六盘水、黔西南州和铜仁市以EV-A71感染为主,其他6个市(州)以其他EV感染为主。3-5月为感染季节高峰,1岁组为感染年龄高峰。轻型病例以其他EV感染居多(48.17%),重症和死亡病例以EV-A71(51.42%和83.64%)居多。结论贵州省大部分地区HFMD流行的病原谱发生变化,需进一步加强监测工作。
[Abstract]:Objective to understand the spectrum composition and distribution of hand foot and mouth disease (HFMD) from 2008 to 2015 in Guizhou Province, and to provide reference for HFMD prevention and control.Methods HFMD cases and clinical information were collected from various cities (states) of Guizhou Province, and Real time-PCR was used to detect the infection of enterovirus.Results A total of 30 069 HFMD specimens were collected and detected from 2008 to 2015, of which 16 122 were EV positive and 53.622 were positive.Of the EV positive specimens, 5 004 were positive for enterovirus A71 (EV-A71) and 31. 04 for Coxsackie virus A16 (CV-A16). 3 532 were positive for Coxsackie virus A16 (CV-A16) and 145 were positive for EV-A71 and CV-A16.In Liupanshui, Qianxinan and Tongren prefectures, EV-A71 infection was predominant in the other 6 cities (prefectures). The peak of infection season was in March and May. The peak age of infection was 1 year old group in other 6 cities (prefectures).The majority of mild cases were other EV infections (48.17%), and the most severe cases and death cases were EV-A71 (51.42%) and EV-A (83.64%).Conclusion the epidemiological spectrum of HFMD in most areas of Guizhou Province changes, so the monitoring work should be strengthened.
【作者单位】：贵州省疾病预防控制中心;遵义医学院医学与生物学研究中心;
【基金】：“十二五”国家科技重大专项(2012ZX1004-212) 贵州省疾病预防控制中心基金项目(2016-E1-3青);贵州省疾病预防控制中心基金项目(2016-E2-6) 贵州省卫生计生委科学技术基金项目(gzwjkj2016-1-053) 贵州省普通高等学校传染病与生物安全特色重点实验室开放基金项目(K-009);贵州省普通高等学校传染病与生物安全特色重点实验室项目(黔教合KY字[2015]331)
【分类号】：R181.8;R725.1

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