降钙素原与C-反应蛋白联合评分系统诊断儿童侵袭性细菌性腹泻

发布时间：2018-04-16 19:27

本文选题：降钙素原 + C-反应蛋白　；参考：《临床儿科杂志》2017年10期

【摘要】：目的构建血降钙素原与C-反应蛋白联合评分系统以诊断儿童侵袭性细菌性腹泻。方法回顾性收集住院的急性腹泻病患儿的临床资料,将患儿分为侵袭性细菌性腹泻组与非细菌性腹泻组。以血降钙素原与C-反应蛋白为参数,通过二分类logistic回归分析构建诊断儿童侵袭性细菌性腹泻的联合评分系统,利用受试者工作特征(ROC)曲线评价其诊断准确性。结果共纳入侵袭性细菌性腹泻患儿110例与非细菌性腹泻患儿108例。侵袭性细菌性腹泻组的血降钙素原与C-反应蛋白水平明显高于非细菌性腹泻组,差异有统计学意义(P均0.05)。构建的联合评分系统诊断侵袭性细菌性腹泻的ROC曲线下面积(AUC)为0.894,大于血降钙素原或C-反应蛋白(P0.05);联合评分的最佳诊断界值为0.52,其灵敏度为80.9%,特异度为88.9%。结论血降钙素原与C-反应蛋白联合评分系统对儿童侵袭性细菌性腹泻诊断准确性良好,可协助临床早期准确诊断。
[Abstract]:Objective to construct a combined serum calcitonin and c-reactive protein scoring system for the diagnosis of invasive bacterial diarrhea in children.Methods Clinical data of hospitalized children with acute diarrhea were retrospectively collected and divided into invasive bacterial diarrhea group and non bacterial diarrhea group.Based on the parameters of serum procalcitonin and C-reactive protein, a combined scoring system for the diagnosis of aggressive bacterial diarrhea in children was constructed by two-classification logistic regression analysis. The diagnostic accuracy was evaluated by using the operating characteristics of subjects.Results 110 cases of invasive bacterial diarrhea and 108 cases of non-bacterial diarrhea were included.The levels of serum procalcitonin and C-reactive protein in invasive bacterial diarrhea group were significantly higher than those in non-bacterial diarrhea group (P < 0.05).The area under the ROC curve of the combined scoring system for the diagnosis of aggressive bacterial diarrhea was 0.894, which was larger than that of the serum procalcitonin or C-reactive protein (P0.05), and the best diagnostic threshold was 0.52.The sensitivity was 80.9 and the specificity was 88.9.Conclusion the combined assessment system of serum procalcitonin and C-reactive protein is accurate in the diagnosis of invasive bacterial diarrhea in children, and can be helpful to the early diagnosis of bacterial diarrhea in children.
【作者单位】：江西省儿童医院消化科;江西省儿童医院检验科;
【基金】：江西省卫生计生委科技计划课题(No.20165502)
【分类号】：R725.7

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