儿童过敏性紫癜肾损害舌象相关性研究

发布时间：2018-04-17 01:27

  本文选题：过敏性紫癜 + 肾脏损害　； 参考：《辽宁中医药大学》2012年硕士论文

【摘要】：目的：通过对225例过敏性紫癜（HSP）住院患儿的回顾性调查分析，观察过敏性紫癜患儿的舌象与肾损害发生的相关性，从而更好地辨别过敏性紫癜肾损害（HSPN）的致病因素，为HSPN的辩证治疗提供更准确的依据，为以后的临床应用及研究提供资料。 方法：采用回顾性研究方法，对2008年12月至2010年12月在辽宁中医药大学附属医院儿科住院的初发或复发的HSP患儿按照是否有肾脏损害进行分组，选取性别、年龄、发病季节、诱因、舌象作为研究因素，所得数据应用SPSS15.0统计软件处理，单因素分析采用χ2检验，多因素分析采用非条件二分类变量的Logistic回归分析。 结果：1.患儿的一般资料：本组225例患儿中发生肾损害患儿91例，未发生肾损害患儿134例；其中男性患儿113例，女性患儿112例，男女比例约为1:1；患儿年龄分布在3~16岁，平均8.458±0.113岁；本组病例的发病季节呈四季散发，但以冬春季节略为多发，各季节所占比例分别为：春季30%，夏季18%，秋季24%，冬季28%；发病多为无明确诱因，，共140例，有明确诱因者共85例，其中上呼吸道感染最多，共75例；西医临床分型：肾型患儿所占比例较大，占28.9%；单纯皮肤型16%；腹型25.3%；关节型10.7%；混型19.1%；中医证型比较：风热伤络型4.9%；血热妄行型55.6%；湿热瘀阻31.6%；阴虚火旺4.0%；气不摄血4.0%。2.对设定的研究因素进行单因素分析，χ2检验结果显示：两组的性别构成、发病诱因、季节构成无明显差别（P0.05）；年龄7岁（包括7岁）、发病季节冬季、舌质红舌、舌苔黄苔及厚腻苔与肾脏损害的发生有密切关系，有统计学意义（P0.05或P0.083）。3.对性别、年龄、诱因、季节、舌质红舌、舌苔黄苔及厚腻苔等7项相关因素进行非条件二分类变量的Logistic回归分析，结果显示：年龄≥7岁、冬季、红舌、厚腻苔可能是HSP患儿发生肾脏损害的重要相关因素。 结论：1.过敏性紫癜肾损害的发生可能与年龄≥7岁、冬季、红舌、厚腻苔有相关性。2.湿邪、热邪为过敏性紫癜肾损害的主要致病因素。3.热邪为过敏性紫癜非肾损害的主要致病因素。
[Abstract]:Objective: to observe the correlation between tongue appearance and renal damage in 225 hospitalized children with Henoch-Schonlein purpura (HSPN), so as to better identify the pathogenic factors of HSPNs in Henoch-Schonlein purpura (Henoch-Schonlein purpura).To provide a more accurate basis for the dialectical treatment of HSPN, and to provide data for clinical application and research in the future.Methods: a retrospective study was carried out on children with HSP who were hospitalized in pediatrics department of Liaoning University of traditional Chinese Medicine from December 2008 to December 2010 according to whether they had kidney damage or not. Sex, age, onset season were selected.The data were processed by SPSS15.0 software, 蠂 2 test was used for univariate analysis and Logistic regression analysis was used for multivariate analysis.The result is 1: 1.General data of children: there were 91 cases of renal damage and 134 cases of no renal damage in this group, including 113 cases of male and 112 cases of female, the ratio of male to female was about 1: 1, the age of the children was 8.458 卤0.113 years old (mean, 8.458 卤0.113 years).The incidence season of this group of cases is seasonal sporadic, but slightly more frequent in winter and spring seasons. The proportion of each season is 30 in spring, 18 in summer, 24 in autumn and 28 in winter, the incidence of which is mostly without definite inducement, 140 cases, 85 cases with definite inducement, the proportion of each season is: 30 in spring, 18 in summer, 24 in autumn and 28 in winter.There were 75 cases of upper respiratory tract infection, the clinical classification of western medicine: the proportion of children with renal type was large.28. 9; skin type 16; abdominal type 25. 3; joint type 10. 7; mixed type 19. 1; TCM syndromes comparison: wind and heat injury collateral type 4. 9; blood heat type 55.6; damp-heat stasis 31. 6; Yin deficiency fire flourishing 4. 0; qi not absorbing blood 4. 0. 2.Univariate analysis showed that there were no significant differences in sex composition, onset inducement and seasonal composition between the two groups, age 7 years (including 7 years old, onset season and winter), tongue red tongue, and the age of 7 years old (including 7 years old, onset season and winter) were not significantly different between the two groups.Yellow tongue coating and thick greasy coating were closely related to the occurrence of renal damage, with statistical significance (P0.05) or P0.083 ~ (3). 3.The factors related to sex, age, inducement, season, tongue red tongue, yellow tongue coating and thick and greasy tongue coating were analyzed by Logistic regression analysis. The results showed that age 鈮

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