早产儿暂时性甲状腺功能减退的临床研究

发布时间：2018-04-17 16:56

本文选题：早产儿 + 暂时性　；参考：《青岛大学》2012年硕士论文

【摘要】：目的研究早产儿暂时性甲状腺功能减退(TH)的发生率与胎龄、出生体重、疾病的关系及其临床表现。方法选取196例早产儿,于生后第7天应用电化学发光法检测其甲状腺素(T4)、游离甲状腺素(FT4)、三碘甲状腺原氨酸(T3)、游离三碘甲状腺原氨酸(FT3)、促甲状腺激素(TSH),并分析其与出生胎龄、出生体重关系,同时调查2周时恢复出生体重例数、规律排便例数以及新生儿黄疸严重程度,进行比较。结果1.本组研究TH阳性率为35.7%(70/196)。 2.男、女性之间TH阳性率无差异(p0.05)。极低出生体重组与对照组之间TH阳性率有差异(p0.05)、小胎龄组与大胎龄组之间TH阳性率有差异(p0.01)、新生儿缺氧缺血性脑病(HIE)组与非HIE组之间TH阳性率有差异(p0.01)、新生儿呼吸窘迫(NRDS)组与非NRDS组之间TH阳性率有差异(p0.01)、感染组与非感染组之间TH阳性率有差异(p0.01)、多种疾病组与对照组之间TH阳性率有差异(p0.01) 3.TH组的胎龄和出生体重明显低于非TH组(两组均p0.01)。 4.在TH组,生后14天恢复出生体重率(p0.005)、规律自主排便率(p0.01))均低于非TH组,新生儿黄疸存在数两组无差异(P0.05)。结论：本组调查表明早产儿TH的发生率为35.7%,本病的发生与胎龄、出生体重密切相关,患有疾病(HIE、NRDS、感染、多种疾病)的早产儿其发生率更高。
[Abstract]:Objective to study the relationship between the incidence of transient hypothyroidism and gestational age, birth weight, disease and its clinical manifestations in premature infants.Methods on the 7th day after birth, 196 premature infants were detected by electrochemiluminescence (ECL) for thyroxine, free thyroxine, triiodothyronine, free triiodothyronine, free triiodothyronine, thyrotropin and TSHN, and their age at birth was analyzed.The relationship between birth weight and recovery of birth weight, regular defecation and the severity of jaundice in newborns were investigated at the same time.Result 1.The positive rate of th in this study was 35.7%.2.There was no difference in th positive rate between male and female.There were significant differences in th positive rate between very low birth weight group and control group, between small gestational age group and large gestational age group, between small gestational age group and large gestational age group, and between HIE group and non HIE group.There was significant difference in th positive rate between NRDS group and non-NRDS group, between infected group and non-infected group, between infected group and non-infected group (p0.01), and between various disease groups and control group (p0.01).The gestational age and birth weight of 3.TH group were significantly lower than that of non th group (p0.01).4.In th group, the recovery rate of birth weight and regular spontaneous defecation rate at 14 days after birth were lower than those in non-TH group. There was no difference in the number of neonatal jaundice between the two groups (P 0.05).Conclusion: the incidence of th in premature infants is 35.70.The incidence of th is closely related to gestational age, birth weight, and the incidence of HIENRDS (infection, multiple diseases) is higher in preterm infants.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R722.6

【参考文献】