痰热清注射液联合阿奇霉素治疗小儿支原体肺炎的疗效及对炎症因子的影响

发布时间：2018-04-18 00:39

本文选题：小儿支原体肺炎 + 痰热清注射液　；参考：《中华中医药学刊》2017年09期

【摘要】：目的:探讨痰热清注射液联合阿奇霉素治疗小儿支原体肺炎的临床疗效及对机体炎症因子的影响。方法:选择儿科治疗的确诊为小儿支原体肺炎的72例患儿作为观察对象,采用随机数字表法将其分为观察组和对照组各36例,均给予院内常规诊疗及护理措施,对照组在以上基础上给予阿奇霉素静脉滴注治疗,观察组在对照组基础上联合应用痰热清注射液静脉滴注治疗,治疗10~14 d,对比两组患儿临床疗效及机体炎症因子水平的变化。结果:观察组总有效率97.22%显著高于对照组的83.33%,两组比较差异有统计学意义(P0.05);观察组患儿咳嗽、发热、肺部阴影及肺部罗音消失时间均明显短于对照组,两组比较差异有统计学意义(P0.05);两组治疗3 d时TNF-α、IL-6及CRP指标均有所下降,与治疗前比较差异均有统计学意义(P0.05),但观察组改善更明显,组间比较有显著性差异(P0.05);治疗6 d时各炎性因子指标下降更为显著,与治疗前比较差异均有统计学意义(P0.05),且观察组改善更为明显,组间比较有显著性差异(P0.05)。结论:痰热清注射液能在一定程度上明显降低患儿肺炎血清中的各类炎性因子的水平,且临床与阿奇霉素联用过程中未见明显不良反应,值得临床推广应用。
[Abstract]:Objective: to investigate the effect of Tanreqing injection combined with azithromycin on mycoplasma pneumonia in children.Methods: a total of 72 children with mycoplasma pneumonia in pediatrics were selected as observation objects. They were divided into observation group (n = 36) and control group (n = 36) by random digital table. All of them were given routine diagnosis and nursing measures in hospital.The control group was treated with azithromycin intravenous drip on the above basis, and the observation group was treated with Tanreqing injection for 10 ~ 14 days on the basis of the control group. The changes of the clinical efficacy and the level of inflammatory factors in the body were compared between the two groups.Results: the total effective rate of the observation group was 97.22% higher than that of the control group (83.33%), the difference between the two groups was statistically significant (P 0.05), the time of cough, fever, lung shadow and rale disappearance in the observation group was significantly shorter than that in the control group.There was a significant difference between the two groups (P 0.05), the indexes of TNF- 伪 IL-6 and CRP decreased at 3 d after treatment, and there was significant difference between the two groups (P 0.05), but the improvement was more obvious in the observation group.There was a significant difference between the two groups (P 0.05), and after 6 days of treatment, all the inflammatory factors decreased more significantly, and the difference was statistically significant compared with that before treatment. The improvement of the observation group was more obvious, and there was a significant difference between the two groups (P 0.05).Conclusion: Tanreqing injection can obviously reduce the level of various inflammatory factors in the serum of children with pneumonia to a certain extent, and there is no obvious adverse reaction in the course of clinical treatment with azithromycin, which is worth popularizing in clinic.
【作者单位】：海口市第三人民医院儿科;
【基金】：海南省自然科学基金项目(20168293)
【分类号】：R725.6

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