EB病毒感染对儿童传染性单核细胞增多症T细胞亚群的影响

发布时间：2018-04-17 21:04

本文选题：疱疹病毒型 + 人　；参考：《重庆医学》2017年25期

【摘要】：目的观察EB病毒(EBV)感染对儿童传染性单核细胞增多症(IM)T细胞亚群的影响。方法选取2013年1月至2016年1月陕西省汉中市人民医院儿科收治的80例IM患儿作为研究对象,所有患儿均接受抗病毒治疗,观察患儿治疗后的EBV-DNA转阴率。比较EBV-DNA阳性及阴性患儿的T细胞亚群分布,分析EBV-DNA未转阴的相关因素。结果经过治疗后,67例(83.75%)患儿EBV-DNA转阴。治疗后,EBV-DNA阴性组CD3~+和CD8~+比例低于EBV-DNA阳性组,CD4~+比例和CD4~+/CD8~+高于EBV-DNA阳性组,差异有统计学意义(P0.05)。对患儿EBV-DNA未转阴的相关因素进行分析:性别、白细胞计数(WBC)及淋巴细胞计数与EBV-DNA转阴无相关性(P0.05),干扰素的使用、年龄及初始Ct与EBV-DNA未转阴具有相关性(P0.05)。结论 EB病毒感染可以引起IM患儿T细胞亚群的紊乱,临床上应采取积极的抗病毒治疗。
[Abstract]:Objective to observe the effect of EBV (EB virus) infection on the subsets of IMT cells in children with infectious mononucleosis.Methods from January 2013 to January 2016, 80 children with IM were selected from the pediatrics department of Hanzhong people's Hospital of Shaanxi Province as study objects. All the children were treated with antiviral therapy, and the rate of EBV-DNA negative was observed.The distribution of T cell subsets in EBV-DNA positive and negative children was compared, and the related factors of negative EBV-DNA were analyzed.Results 67 children with EBV-DNA turned negative after treatment.The ratio of CD3 ~ and CD8 ~ in EBV-DNA negative group was lower than that in EBV-DNA positive group and CD4 ~ / / CD8 ~ + group was higher than that in EBV-DNA positive group, the difference was statistically significant (P 0.05).The factors related to the negative conversion of EBV-DNA in children were analyzed: sex, white blood cell count (WBC) and lymphocyte count were not correlated with the negative conversion of EBV-DNA (P 0.05). The use of interferon, age and initial Ct were correlated with the negative conversion of EBV-DNA (P 0.05).Conclusion Epstein-Barr virus infection can cause disorder of T cell subsets in IM children.
【作者单位】：陕西省汉中市人民医院儿科;西安交通大学第二附属医院呼吸内科;
【基金】：国家自然科学基金资助项目(81000009)
【分类号】：R725.1

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