儿童性早熟与生活方式及家族因素的相关性研究

发布时间：2018-04-18 10:05

  本文选题：性早熟 + 肥胖　； 参考：《杭州师范大学》2017年硕士论文

【摘要】：目的:了解性早熟儿童和正常健康儿童生长发育水平差异,探讨儿童性早熟与生活方式及家族因素的相关性,并提出预防儿童性早熟的相关措施和建议,为有针对性地开展儿童性早熟的防治工作提供科学依据。方法:采用病例对照研究方法,按照一定的纳入排除标准选取2015年6月—2016年8月在金华市妇保院和杭州师范大学附属医院小儿内分泌科初诊并确诊为中枢性性早熟的儿童126名作为病例组,按性别年龄成组匹配的正常体检儿童126名作为对照组,对其进行生长发育状况的评定和问卷调查。生长发育状况的评定包括体格测量、第二性征评价、骨龄的测量、性激素基础值的测定及Gn RH激发试验等,问卷调查的主要内容包括儿童的一般资料、出生状况和母孕期状况、饮食习惯、生活方式、遗传因素、社会经济状态、家庭环境和家长陪伴共七个方面。采用SPSS20.0处理数据,用t检验、c2检验和秩和检验进行单因素分析,并用二元Logistic回归筛选出相关影响因素。结果:(1)病例组儿童身高、体重、BMI、骨龄均高于对照组,且病例组肥胖检出率(26.2%)高于对照组(14.3%),差异均具有统计学意义(p0.05)。(2)根据单因素分析的结果,BMI、是否肥胖、有无午睡习惯、运动时间、食量大小、母亲初潮年龄、家庭亲属中有无性早熟、父亲学历、母亲学历、父亲职业、母亲职业、与父亲亲密程度、父亲不在一起时间、父亲陪伴共14个因素与儿童性早熟有关联;二元Logistic回归分析结果显示,不午睡(OR=3.135,p0.001)、食量(OR=1.944,p=0.002)与性早熟呈正相关;母亲学历(OR=0.576,p=0.004)、母亲初潮年龄(OR=0.645,p0.001)、父亲陪伴(OR=0.763,p=0.038)与性早熟呈负相关。结论:(1)在同一基线水平下,病例组儿童生长发育水平暂时高于对照组。(2)母亲初潮年龄早、食量大、父亲陪伴少是性早熟的危险因素,母亲学历高、有午睡习惯是性早熟的保护因素。应加强健康知识教育,培养儿童健康的饮食习惯和生活习惯,鼓励家长多陪伴儿童,并完善儿童健康管理服务流程。
[Abstract]:Objective: to investigate the difference of growth and development level between children with sexual precocious puberty and healthy children, to explore the correlation between precocious puberty and lifestyle and family factors, and to put forward relevant measures and suggestions to prevent precocious puberty in children.To provide scientific basis for the prevention and cure of precocious puberty of children.Methods: a case-control study was conducted.According to certain exclusion criteria, 126 children with central precocious puberty were selected as the case group from June 2015 to August 2016 in the Department of Pediatric Endocrinology of Jinhua Municipal Women's Insurance Hospital and the affiliated Hospital of Hangzhou normal University.126 normal children matched by sex and age were used as control group to evaluate their growth and development status.The evaluation of growth and development includes physical measurement, evaluation of secondary sexual characteristics, measurement of bone age, measurement of basic sex hormone value and GnRH stimulation test, etc. The main contents of the questionnaire include general data of children, birth status and maternal pregnancy status.Eating habits, lifestyle, genetic factors, socioeconomic status, family environment and parental companionship are seven aspects.The data were processed by SPSS20.0, single factor analysis was carried out by t test c2 test and rank sum test, and correlation factors were screened by binary Logistic regression.Results (1) the height, weight and bone age of the children in the case group were higher than those in the control group, and the prevalence rate of obesity in the case group was 26.2) higher than that in the control group. The difference was statistically significant (P < 0.05). 2) according to the results of univariate analysis, BMIs were obese and had the habit of napping.Time of exercise, amount of food, age of mother's menarche, asexual precocious among family relatives, father's education, mother's education, father's occupation, mother's occupation, degree of intimacy with father, father's absence time,The results of binary Logistic regression analysis showed that there was a positive correlation between precocious puberty and sex precocious puberty without napping (3.135%) and eating quantity (1.944%), and a negative correlation between precocious puberty and precocious puberty was found in mother's education (OR 0.576), mother's age at menarche (OR 0.645p 0.001) and father's accompanying ORA (0.763p0. 038).Conclusion: under the same baseline level, the growth and development level of children in the case group was temporarily higher than that in the control group.) the maternal age of menarche was early, the amount of food was large, the father accompanied less was the risk factor of precocious puberty, and the mother had a high degree of education.Having a habit of siesta is a protective factor for precocious puberty.Health knowledge education should be strengthened, healthy eating habits and living habits should be cultivated, parents should be encouraged to accompany their children more, and children health management service flow should be perfected.
【学位授予单位】：杭州师范大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R725.8
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本文编号：1767896