中国儿童及青少年幽门螺杆菌感染流行病学调查的系统评价和meta分析

发布时间：2018-04-18 12:51

本文选题：幽门螺杆菌 + 流行病学　；参考：《临床儿科杂志》2017年10期

【摘要】：目的系统评价中国儿童及青少年幽门螺杆菌(H.pylori)感染的流行病学特征。方法检索Pub Med、EMBASE、Cochrane图书馆、中国知网、万方数据库,检索起止时间为建库至2016年9月。2名研究者根据纳入与排除标准筛选文献,采用AHRQ量表评估文献质量,使用Stata 12.0软件进行meta分析。结果 7篇文献纳入meta分析,涉及16 950名儿童及青少年。中国自然人群儿童及青少年H.pylori总感染率为29%(95%CI:0.18~0.40);儿童及青少年H.pylori感染呈显著的地域分布性差异,在胃癌低发区,中国自然人群儿童H.pylori总感染率为20%(95%CI:0.13~0.28),在胃癌高发区H.pylori总感染率高达55%(95%CI:0.21~0.89);男性与女性H.pylori感染率无显著差异;≤1岁、~5岁、~10岁、~15岁、~18岁儿童及青少年的H.pylori感染率分别为17.8%、8%、19%、26%、45%,随年龄增长H.pylori感染率有上升趋势;农村儿童及青少年H.pylori感染风险是城市的1.25倍;有消化道症状的农村儿童及青少年H.pylori感染风险比无消化道症状者高2.2倍。结论中国自然人群儿童及青少年H.pylori总感染率为29%,呈现显著的地域分布性差异,胃癌高发区H.pylori感染率是胃癌低发区的2.8倍。仍需后续高质量、大样本量流行病学调查,以进一步明确中国儿童及青少年H.pylori感染情况。
[Abstract]:Objective to evaluate the epidemiological characteristics of H. pylori infection in Chinese children and adolescents.Methods the Pub Medbin EMBASE Cochrane Library, China knowledge Network and Wanfang database were searched. The literature quality was evaluated by AHRQ scale according to the inclusion and exclusion criteria from the beginning to the end of the database construction until September 2016.Meta analysis was carried out with Stata 12.0 software.Results Seven articles were included in meta analysis, involving 16 950 children and adolescents.The total infection rate of H.pylori in children and adolescents of natural population in China was 2995 CI: 0.180.400.The distribution of H.pylori infection in children and adolescents was significant difference in the low incidence area of gastric cancer.The total infection rate of H.pylori in Chinese natural population was 20 / 95. The total infection rate of H.pylori was as high as 55 ~ 95CI: 0.21 ~ 0.89 in the area with high incidence of gastric cancer. There was no significant difference between male and female in H.pylori infection rate.The infection rate of H.pylori in children and adolescents aged 15 and 18 years old was 17.80.The infection rate of H.pylori increased with the increase of age, and the risk of H.pylori infection in rural children and adolescents was 1.25 times higher than that in urban areas.The risk of H.pylori infection in rural children and adolescents with digestive tract symptoms was 2.2 times higher than that without gastrointestinal symptoms.Conclusion the total infection rate of H.pylori in children and adolescents of Chinese natural population is 29, showing significant regional distribution difference. The H.pylori infection rate in the high incidence area of gastric cancer is 2.8 times higher than that in the low incidence area of gastric cancer.High quality and large sample epidemiological investigation is still needed to further clarify the H.pylori infection in Chinese children and adolescents.
【作者单位】：兰州大学第一临床医学院;甘肃省胃肠病重点实验室;兰州大学第二医院;
【基金】：国家自然科学基金面上项目(No.81372145) 兰州大学中央高校基本科研业务费专项资金(No.lzujbky-2013-157) 兰州大学第一医院院内基金(No.ldyyynqn201203)
【分类号】：R725.7

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