苍附导痰汤加减治疗男童乳房发育症肝郁痰凝型的临床观察

发布时间：2018-04-19 14:49

本文选题：苍附导痰汤 + 男童乳房发育症　；参考：《黑龙江中医药大学》2017年硕士论文

【摘要】：目的:探讨苍附导痰汤加减治疗男性儿童乳房发育症肝郁痰凝型的临床疗效;观察苍附导痰汤加减对患儿血清睾酮、雌二醇水平的影响。方法:选定符合纳入标准的男性儿童乳房发育症患者共60例,随机分为治疗组和对照组各30例。治疗组给予口服中药汤剂苍附导痰汤加减,对照组给予口服逍遥丸。观察周期为8周。8周后记录两组患者乳房症状积分和中医症候积分,进行疗效及安全性评估。检测比较治疗前后患儿血清睾酮、雌二醇水平。疗程结束2个月后对两组痊愈患儿进行随访,记录并对比复发率。结果:1.临床总疗效:治疗组的总有效率为93.3%,对照组的总有效率为70.0%,治疗组的总疗效率明显优于对照组(P0.05)。2.乳房及中医症候积分比较:两组患者治疗前后在乳房疼痛、肿块大小、肿块硬度和中医症候四个方面积分的差异均具有统计学意义(P0.05);两组患者治疗后,组间差异同样具有统计学意义(P0.05),说明两组治疗均能改善患者乳房及中医症候情况,且治疗组优于对照组。激素水平比较:治疗组患者的血清雌二醇和睾酮值在治疗前后差异有统计学意义(P0.05)。3.随访:治疗组复发0例,对照组复发2例。治疗组复发率明显低于对照组(P0.05)。结论:1.苍附导痰汤加减治疗男童乳房发育症肝郁痰凝型疗效明显优于逍遥丸。2.苍附导痰汤加减可改善乳房症状和中医症候;明显提高血清睾酮水平,改善性激素紊乱状态。3.苍附导痰汤加减治疗男童乳房发育症安全、有效,无复发。
[Abstract]:Objective: to investigate the clinical effect of Cangfu Duan phlegm decoction (Cangfu Dantan decoction) on the serum testosterone and estradiol levels in male children with breast development syndrome with stagnation of liver and phlegm coagulation.Methods: 60 male children with breast development were randomly divided into treatment group (n = 30) and control group (n = 30).The treatment group was treated with oral Chinese medicine decoction Cangfu Daophan decoction and the control group with Xiaoyao Pill.The clinical efficacy and safety of the two groups were evaluated after the observation period of 8 weeks and 8 weeks after the breast symptom score and TCM symptom score were recorded.Serum testosterone and estradiol levels were measured before and after treatment.Two months after the course of treatment, the two groups were followed up and the recurrence rate was recorded and compared.The result is 1: 1.Total clinical efficacy: the total effective rate of the treatment group was 93.3 and the total effective rate of the control group was 70.00.The total effective rate of the treatment group was obviously better than that of the control group (P0.050.2.)Comparison of breast and TCM symptom scores: the differences of breast pain, mass size, mass hardness and TCM symptom between the two groups were statistically significant (P 0.05).The difference between the two groups was also statistically significant, indicating that the two groups can improve the breast and TCM symptoms, and the treatment group is better than the control group.Comparison of hormone levels: the serum estradiol and testosterone levels in the treatment group were significantly different before and after treatment.Follow up: there were 0 cases of recurrence in the treatment group and 2 cases in the control group.The recurrence rate in the treatment group was significantly lower than that in the control group (P 0.05).Conclusion 1.The therapeutic effect of Cangfu Daotan decoction in treating boy breast development syndrome with liver depression and phlegm coagulation is obviously better than Xiaoyao Pill. 2.Cangfu Daophan decoction can improve breast symptoms and TCM symptoms, significantly improve serum testosterone level, improve sex hormone disorder state. 3.Cangfu Daophan decoction is safe, effective and no recurrence in treating male breast development.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R272

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