金蝉口服液治疗小儿呼吸道合胞病毒肺炎的有效性与安全性

发布时间：2018-04-23 17:43

本文选题：肺炎 + 儿童　；参考：《中国新药与临床杂志》2017年07期

【摘要】：目的评价金蝉口服液治疗小儿呼吸道合胞病毒肺炎的有效性及安全性。方法采用随机、双盲、安慰剂对照的研究方法。计划收取患儿120例,随机分为两组。试验组予金蝉口服液5~10 m L,每日3次,对照组予同等剂量安慰剂,两组均给予常规对症治疗。观察两组患儿症候改善情况,评估综合疗效。对主症进行生存分析,比较主症起效时间和恢复时间,记录不良反应发生情况。结果共纳入有效病例117例,试验组59例,对照组58例。试验组有效率64%,高于对照组(24%,P0.01),试验组临床疗效优于对照组(P0.01)。试验组咳嗽、咳痰、气促、肺部Up音恢复的起效时间早于对照组(P0.05或P0.01)。试验组患儿住院时间、咳嗽转归时间、咳痰恢复时间、气促恢复时间、肺部Up音消失时间和胸片炎症吸收时间均短于对照组(P0.05或P0.01)。未见严重不良反应发生。结论金蝉口服液治疗小儿呼吸道合胞病毒肺炎有效且安全。
[Abstract]:Objective to evaluate the efficacy and safety of Jincheng oral liquid in the treatment of respiratory syncytial virus pneumonia in children. Methods A randomized, double blind, placebo controlled study was used. 120 patients were randomly divided into two groups. The experimental group was given Jinchan oral liquid for 5 minutes 10 mL, 3 times a day, the control group was given the same dose of placebo, both groups were given routine symptomatic treatment. To observe the improvement of symptoms in the two groups and to evaluate the comprehensive curative effect. Survival analysis was carried out to compare the onset time and recovery time of the main symptom and to record the occurrence of adverse reactions. Results 117 effective cases were included, 59 cases in the trial group and 58 cases in the control group. The effective rate of the test group was 64%, which was higher than that of the control group (24%), and the clinical efficacy of the test group was better than that of the control group (P 0.01). The onset time of cough, expectoration, shortness of breath and the recovery of up in lung in the test group was earlier than that in the control group (P 0.05 or P 0.01). The hospitalization time, cough recovery time, expectoration recovery time, pneumonic recovery time, lung Up disappearance time and chest film inflammatory absorption time in the experimental group were shorter than those in the control group (P0.05 or P0.01). No serious adverse reactions occurred. Conclusion Jincheng oral liquid is effective and safe in the treatment of respiratory syncytial virus pneumonia in children.
【作者单位】：苏州科技城医院;苏州大学附属儿童医院;
【基金】：苏州市科技发展计划项目(ZXY2012010)
【分类号】：R272

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