多巴胺、酚妥拉明、重组干扰素α联合NCPAP治疗婴幼儿重症毛细支气管炎的疗效观察

发布时间：2018-04-24 00:35

本文选题：婴幼儿重症毛细支气管炎 + 多巴胺　；参考：《重庆医学》2017年20期

【摘要】：目的探讨多巴胺、酚妥拉明、重组干扰素α联合经鼻持续气道正压通气(NCPAP)治疗婴幼儿重症毛细支气管炎的临床效果。方法婴幼儿重症毛细支气管炎患儿分为观察组55例和对照组40例,对照组患儿给予多巴胺、酚妥拉明、重组干扰素α联合方案治疗,观察组患儿在此基础上加用NCPAP,比较两组治疗效果。结果观察组患儿总有效率显著高于对照组,患儿体温恢复时间、憋喘消失时间、咳嗽停止时间、肺部哮鸣音消失时间、住院时间显著低于对照组,差异有统计学意义(P0.05)。两组患儿治疗后呼吸频率、心率、PaCO_2水平显著低于治疗前,PaO_2、PaO_2/FiO_2、pH水平显著高于治疗前,差异有统计学意义(P0.05);观察组患儿治疗后呼吸频率、心率、PaCO_2水平显著低于对照组,PaO_2、PaO_2/FiO_2、pH水平显著高于对照组,差异有统计学意义(P0.05)。两组患儿治疗后血清白细胞介素-8(IL-8)、可溶性血管细胞间黏附分子-1(sVCAM-1)及尿白三烯E4(LTE4)水平均显著低于治疗前,差异有统计学意义(P0.05);两组患儿治疗后血清IL-8、sVCAM-1及尿LTE4水平对比,差异无统计学意义(P0.05)。观察组患儿复发率和病死率显著低于对照组,差异有统计学意义(P0.05);两组治疗期间不良情况发生率对比,差异无统计学意义(P0.05)。结论多巴胺、酚妥拉明、重组干扰素α联合NCPAP治疗婴幼儿重症毛细支气管炎临床效果显著,可有效改善患儿血气分析指标,缩短症状体征缓解时间,降低复发率和病死率,临床应用价值较高。
[Abstract]:Objective to investigate the clinical effect of dopamine, phentol Lemine and recombinant interferon 伪 combined with nasal continuous positive airway pressure ventilation (NCPAP) in the treatment of severe bronchiolitis in infants. Methods Children with severe bronchiolitis were divided into observation group (n = 55) and control group (n = 40). The observation group was treated with NCPAP on this basis, and the therapeutic effect was compared between the two groups. Results the total effective rate in the observation group was significantly higher than that in the control group. The recovery time of body temperature, the time of disappearing of asthma, the time of stopping cough, the time of disappearance of lung wheezing and the time of hospitalization were significantly lower in the observation group than in the control group, and the difference was statistically significant (P 0.05). The respiratory frequency, heart rate and Paco _ 2 level in the two groups were significantly lower than those before treatment, and the pH level of the two groups was significantly higher than that before treatment (P 0.05), and the respiratory frequency of the observation group was significantly higher than that of the control group. The level of Paco _ 2 in heart rate and Paco _ 2 was significantly lower than that in the control group (P < 0.05), and the pH value of Paco _ 2 / FiO _ 2 was significantly higher than that of the control group (P < 0.05). After treatment, the levels of serum interleukin-8 (IL-8), soluble vascular adhesion molecule-1 (VCAM-1) and urinary leukotriene E4 (LTE4) were significantly lower than those before treatment (P 0.05), and the levels of serum IL-8 sVCAM-1 and urinary LTE4 were significantly lower than those before treatment. The difference was not statistically significant (P 0.05). The recurrence rate and fatality rate in the observation group were significantly lower than those in the control group, and the difference was statistically significant (P 0.05). Conclusion the clinical effect of dopamine, phentol Lemine, recombinant interferon 伪 and NCPAP in the treatment of infant severe bronchiolitis is remarkable. It can effectively improve the blood gas analysis index, shorten the remission time of symptoms and signs, and reduce the recurrence rate and mortality. The clinical application value is high.
【作者单位】：河北省衡水市哈里逊国际和平医院婴幼儿科;
【分类号】：R725.6

【相似文献】