极低出生体质量早产儿和足月儿外周血T淋巴细胞亚群及血清IgG水平比较

发布时间：2018-04-24 20:10

本文选题：极低出生体质量早产儿 + T淋巴细胞亚群　；参考：《现代免疫学》2017年04期

【摘要】：探讨极低出生体质量早产儿和足月儿外周血中T淋巴细胞亚群及血清IgG水平差异。根据胎盘病理活检结果,选母亲为绒毛膜羊膜炎68例,其对应的极低出生体质量早产儿也为68例,再收集正常母亲及正常出生的婴儿20例作对照。采用流式细胞仪分别检测极低出生体质量早产儿和足月儿外周血中T细胞亚群细胞数量,同时用化学发光法测定极低出生体质量早产儿和足月儿血清中IgG含量。极低出生体质量早产儿外周血CD3~+、CD4~+、CD19~+、CD4~+/CD8~+等T细胞、NK细胞数量明显低于足月儿外周血中T细胞亚群数量,差异有统计学意义(P0.05);而极低出生体质量早产儿外周血CD8+T细胞数量略高于足月儿外周血CD8~+T细胞数量,差异无统计学意义(P0.05);极低出生体质量早产儿血清IgG含量明显低于足月儿血清IgG含量,差异有统计学意义(P0.05);而且极低出生体质量早产儿CD4~+T细胞数量和胎龄呈正相关(P0.05,r=0.619)。极低出生体质量早产儿免疫功能低下,细胞免疫在新生儿免疫中占主导地位,提高新生儿免疫功能将对降低新生儿疾病感染率和病死率具有重要的临床价值。
[Abstract]:To investigate the difference of T lymphocyte subsets and serum IgG levels in peripheral blood of very low birth weight preterm infants and term infants. According to the results of placental pathological biopsy, 68 cases of chorioamnionitis were selected as mothers, 68 cases of premature infants with very low birth weight were selected, and 20 cases of normal mothers and normal infants were collected as control group. The T cell subsets in peripheral blood of very low birth weight preterm infants and term infants were detected by flow cytometry, and the serum IgG levels of very low birth weight preterm infants and term infants were measured by chemiluminescence assay. The number of NK cells in peripheral blood of premature infants with very low birth weight was significantly lower than that of peripheral blood T cell subsets in peripheral blood of very low birth weight preterm infants. The number of CD8 T cells in peripheral blood of premature infants with very low birth weight was slightly higher than that of full-term infants, and the number of CD8T cells in peripheral blood of premature infants with very low birth weight was slightly higher than that of term infants. There was no significant difference in serum IgG content between very low birth weight premature infants and term infants (P 0.05), and there was a positive correlation between the number of CD4T cells and gestational age in very low birth weight premature infants. The immune function of premature infants with very low birth weight is low, and cellular immunity plays a dominant role in neonatal immunity. Improving the immune function of newborns will have important clinical value in reducing neonatal disease infection rate and mortality.
【作者单位】：宁波市妇女儿童医院检验科;
【基金】：宁波市科技计划项目(2013C50011)
【分类号】：R446.6;R722.6

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