过敏性紫癜肾炎嗜酸性粒细胞、中性粒细胞与淋巴细胞的比值及血小板参数的变化意义

发布时间：2018-04-30 09:58

本文选题：过敏性紫癜肾炎 + 中性粒/淋巴细胞比值　；参考：《山西医科大学》2012年硕士论文

【摘要】：目的：近些年来在不同年龄层的儿童人群中过敏性紫癜的发病率持续增高。过敏性紫癜从病理上约100%有肾脏损伤，但有肾损临床表现者约30-50%。影响过敏性紫癜患儿预后的第一要素是肾脏的损害程度。因此从临床角度构建针对过敏性紫癜肾脏损伤趋势的早期预警思路和方法，对指导治疗和确定患儿预后将具有重要意义，至目前国内外相关研究报道还比较少。本研究的目的在于探讨过敏性紫癜患儿外周血中性粒细胞与淋巴细胞的比值、嗜酸粒细胞及血小板参数对过敏性紫癜肾炎发生的预测价值，提高对可能发生不良并发症患儿的检出率，，以便医务人员采取积极措施，降低患儿紫癜性肾炎的发生率。方法：对2010年9月——2011年9月山西医科大学附属第一临床医院收住院的100例处于过敏性紫癜急性期患儿，入院时在未给予任何治疗前抽血检测其血清中性粒细胞，淋巴细胞，嗜酸粒细胞绝对值，血小板各参数，并计算中性粒细胞与淋巴细胞比值。将100例病例按不同性别分为男生组（57例）和女生组（43例）；按入院时是否存在上呼吸道感染感染分为感染者组（39例）和非感染者组（61例）；按入院时是否出现肾脏损害的表现分为肾脏损害组（35例）和肾脏无损害组（65例）。结果：过敏性紫癜肾炎组中性粒细胞与淋巴细胞的比值（2.38±0.13）高于无肾损害组（1.80±0.15）,紫癜肾炎组嗜酸粒细胞（0.35±0.66）较无肾损害组（0.07±0.07）明显升高，差异有统计学意义（P0.01）。过敏性紫癜肾炎组血小板参数（PLT、MPV、PDW）与无肾损害组比较，差异有统计学意义（P0.05）。结论：HSPN患儿外周血NLR和Eo、PLT、MPV、PDW水平显著升高，可以作为一种简便的诊断HSPN的标记物，尤其是对疾病早期的筛查可能具有更好的价值。
[Abstract]:Objective: the incidence of Henoch-Schonlein purpura in children of different ages has been increasing in recent years. About 100% of Henoch-Schonlein purpura had renal injury pathologically, but 30-50% had renal lesion. The first factor affecting the prognosis of children with Henoch-Schonlein purpura is the degree of renal damage. Therefore, it is important to construct an early warning method for the trend of renal injury in Henoch-Schonlein purpura from the clinical point of view, which will be of great significance in guiding the treatment and determining the prognosis of children. The purpose of this study was to investigate the predictive value of the ratio of peripheral blood neutrophils to lymphocytes, eosinophils and platelet parameters in the occurrence of Henoch-Schonlein purpura nephritis in children with Henoch-Schonlein purpura. In order to reduce the incidence of Henoch-Schonlein purpura nephritis (HSPN), medical staff should take active measures to improve the detection rate of children with possible adverse complications. Methods: from September 2010 to September 2011, 100 children in the acute phase of Henoch-Schonlein purpura were collected from the first affiliated Clinical Hospital of Shanxi Medical University, and their serum neutrophils and lymphocytes were detected before receiving any treatment. The absolute value of eosinophils, platelet parameters and the ratio of neutrophils to lymphocytes were calculated. 100 cases were divided into male group (57 cases) and female group (43 cases) according to sex. According to the presence of upper respiratory tract infection at admission, 39 cases were divided into infected group (n = 39) and non-infected group (n = 61). There were 35 cases of renal injury group and 65 cases of no renal injury group. Results: the ratio of neutrophil to lymphocyte in Henoch-Schonlein purpura nephritis group (2.38 卤0.13) was higher than that in no renal lesion group (1.80 卤0.15), and the eosinophils in purpura nephritis group (0.35 卤0.66) was significantly higher than that in no renal lesion group (0.07 卤0.07). The platelet parameters of patients with Henoch-Schonlein purpura nephritis were compared with those without renal lesion (P 0.05). Conclusion the levels of NLR and EOPLT in peripheral blood of children with HSPN were significantly increased, which could be used as a simple marker for the diagnosis of HSPN, especially in the early screening of the disease.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R726.9

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