小儿多汗与特应性体质相关分析研究

发布时间：2018-04-30 09:24

本文选题：多汗症 + 特应性体质/过敏体质　；参考：《复旦大学》2012年硕士论文

【摘要】：背景在临床工作中,我们发现以多汗为主诉就诊患儿逐渐增多,且常继发反复呼吸道感染。另外,不少过敏性疾病患儿家长抱怨孩子平时汗出过多。目前有关多汗与特应性体质相关性的研究,国内外多集中在成人,在儿童中开展的研究资料比较少。因此,本课题探索研究小儿多汗与特应性体质的关系,对于指导小儿多汗症治疗,预防反复呼吸道感染具有重要意义。目的探讨多汗与小儿特应性体质的关系。方法选择2010年8月至2012年3月复旦大学附属上海市第五人民医院儿科门诊及病房诊治患儿90例,根据临床表现分为多汗组(N=45例)和非多汗组(N=45例)。通过对患儿临床资料的分析,探讨出汗与婴儿湿疹、特应性鼻炎、过敏性结膜炎、哮喘的相关性。结果 1.多汗组与非多汗组在性别、年龄、身高、体重、体重指数等基线资料的分布上无明显差异(p0.05)。两组在白细胞计数、嗜酸性粒细胞比例以及血钙、血磷、碱性磷酸酶、免疫球蛋白E的分布上亦无明显差异(p0.05)。 2.多汗组与非多汗组患儿在家族多汗史的分布上有显著差异(p0.05)；两组在家族过敏史的分布上无差异(p0.05)。 3.多汗组与非多汗组在婴儿湿疹、变应性鼻炎及过敏性结膜炎的分布上无明显差异(p0.05)；多汗组哮喘患病率以及过敏原阳性率均高于非多汗组(p0.05)。结论 1.小儿常见头颈、躯干等部位多汗。 2.多汗患儿常伴有家族多汗史。 3.哮喘、皮肤点刺试验过敏原阳性是小儿多汗的危险因素,提示多汗可能与特应性体质相关。背景支气管哮喘是儿童常见呼吸道慢性疾病之一。随着《全球哮喘防治创议》(GINA)方案在各国的推广和实施,全球哮喘的诊断和治疗得以统一化和规范化,哮喘的诊断和治疗水平得到了明显的提高,但哮喘,尤其是小儿哮喘的患病率仍呈不断上升趋势。临床工作中,我们发现不少哮喘患儿家长抱怨孩子出汗多,此症状进一步诱发了反复呼吸道感染及哮喘发作,形成了恶性循环,并对孩子的健康造成了一定的伤害。但目前国内外针对小儿哮喘与多汗关系的研究文献较少见,国外研究多集中在成人。因此,本课题探讨哮喘患儿安静时多汗状况及其相关危险因素,以期进一步加强对小儿哮喘的诊断与治疗。目的了解哮喘患儿中多汗患病率及多汗的危险因素。方法选择2010年8月至2012年3月随访于复旦大学附属上海市第五人民医院儿科门诊及病房诊断明确的哮喘患儿55例,根据临床表现分为多汗组(N=35例)和非多汗组(N=20例)。通过对患儿临床资料的统计分析,了解哮喘患儿中多汗发病率,对多汗与婴儿湿疹、特应性鼻炎、过敏性结膜炎的关系进行分析。结果 1.哮喘多汗组与非多汗组在性别、年龄、身高、体重、体重指数等基线资料的分布上无明显差异(p0.05)。两组在血钙、血磷、碱性磷酸酶、免疫球蛋白E、嗜酸性粒细胞比例的分布上亦无明显差异(p0.05)。 2.两组患儿在家族多汗史及过敏史的分布上均无差异(p0.05)。 3.两组患儿在婴儿湿疹、结膜炎的分布上无明显差异(p0.05)；哮喘多汗组变应性鼻炎发病率高于非多汗组(p0.05)。两组过敏原阳性率无差异(p0.05)。结论 1.哮喘多汗患病率为35/55,约63%。 2.变应性鼻炎是哮喘患儿多汗的危险因素。
[Abstract]:background
In clinical work, we found that children with sweating as the main complaint are gradually increasing and often secondary respiratory infection. In addition, many parents of children with allergic diseases complain about the excessive sweat in children. At present, the study on the correlation between hyperhidrosis and atopic constitution is concentrated in adults at home and abroad, and the research data in children are compared. Therefore, it is of great significance to study the relationship between children's hyperhidrosis and atopic constitution in order to guide the treatment of hyperhidrosis and prevent recurrent respiratory infection.
objective
To explore the relationship between hyperhidrosis and children's atopic constitution.
Method
From August 2010 to March 2012, 90 children were diagnosed and treated in the outpatient department of Pediatrics and ward of the Fifth People's Hospital of Shanghai, Shanghai, which were divided into the hyperhidrosis group (N=45) and the non hyperhidrosis group (N=45) according to the clinical manifestations. Through the analysis of the clinical data of the children, the perspiration was related to the infant's wet rash, atopic rhinitis, allergic conjunctivitis, and asthma. Sex.
Result
There was no significant difference in the distribution of baseline data of sex, age, height, weight and body mass index between the 1. perspiration group and the non perspiration group (P0.05). There was no significant difference in the distribution of leukocyte count, eosinophil ratio and blood calcium, blood phosphorus, alkaline phosphatase and immunoglobulin E in the two groups (P0.05).
2. there was a significant difference in the distribution of familial hyperhidrosis between hyperhidrosis group and non hyperhidrosis group (P0.05), and there was no difference in the family history of allergy between the two groups (P0.05).
There was no significant difference in the distribution of eczema, allergic rhinitis and allergic conjunctivitis between the 3. perspiration group and the non perspiration group (P0.05). The prevalence of asthma and the positive rate of allergen were higher in the hyperhidrosis group than in the non hyperhidrosis group (P0.05).
conclusion
1. the common head and neck of children, the trunk and other parts are sweaty.
2. Chang Banyou family, the history of perspiration in the family of children with perspiration.
3. asthma, skin prick test, allergen positive is a risk factor for hyperhidrosis in children, suggesting that hyperhidrosis may be related to atopic constitution.
background
Bronchial asthma is one of the common chronic respiratory diseases in children. With the promotion and implementation of the global proposal for asthma prevention and treatment (GINA) in various countries, the diagnosis and treatment of asthma in the world are unified and standardized, the diagnosis and treatment of asthma have been significantly improved, but the prevalence of asthma, especially in children's asthma, is still continuing. In clinical work, we have found that many parents of children with asthma complain that children are sweating more, which further induce recurrent respiratory infection and asthma attacks, forming a vicious cycle and causing certain harm to the health of children. However, the research literature on the relationship between children's asthma and hyperhidrosis is rare at home and abroad. Therefore, the subject is to explore the perspiration and related risk factors of children with asthma in silence in order to further strengthen the diagnosis and treatment of children with asthma.
objective
Objective to understand the prevalence of sweating and risk factors for sweating in asthmatic children.
Method
From August 2010 to March 2012, 55 cases of asthma in the outpatient department of Pediatrics and ward of the Fifth People's Hospital of Shanghai, Shanghai, affiliated to Fudan University, were selected. According to the clinical manifestations, the patients were divided into the hyperhidrosis group (N=35) and the non sweaty group (N=20). The incidence of hyperhidrosis in the children with asthma was analyzed by the statistical analysis of the clinical data of the children. The relationship between infantile eczema, atopic rhinitis and allergic conjunctivitis was analyzed.
Result
There was no significant difference in the distribution of baseline data on sex, age, height, weight and body mass index (P0.05). There was no significant difference in the distribution of blood calcium, blood phosphorus, alkaline phosphatase, immunoglobulin E and eosinophil (P0.05) in the two groups of asthma and hyperhidrosis (P0.05).
2. there was no difference in the distribution of family history of sweating and allergy between the two groups (P0.05).
There was no significant difference in the distribution of conjunctivitis between the 3. children and the two groups (P0.05), and the incidence of allergic rhinitis in the hyperhidrosis group was higher than that in the non perspiration group (P0.05). There was no difference in the positive rate of allergens in the two groups (P0.05).
conclusion
1. the prevalence of hyperhidrosis in asthma was 35/55, about 63%.
2. allergic rhinitis is a risk factor for hyperhidrosis in asthmatic children.

【学位授予单位】：复旦大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R725.6

【参考文献】