西替利嗪口服溶液联合布地奈德混悬液治疗小儿急性哮喘的临床研究

发布时间：2018-05-01 21:41

本文选题：西替利嗪口服溶液 + 布地奈德混悬液　；参考：《中国临床药理学杂志》2017年11期

【摘要】：目的观察西替利嗪口服溶液联合布地奈德混悬液治疗小儿急性哮喘的临床疗效和安全性。方法将86例急性哮喘患儿随机分为对照组43例和试验组43例。对照组予以布地奈德每次1.0 mg,bid,每次15 min,雾化治疗;试验组在对照组治疗的基础上,予以西替利嗪口服溶液每次10 m L,bid,口服。2组患儿均治疗7 d。比较2组患儿的临床疗效、用力肺活量(FVC)、第1秒用力呼气量(FEV1)、用力呼气中期流速(MMF)和最大通气量(MVV)和药物不良反应的发生情况。结果治疗后,试验组和对照组的总有效率分别为95.35%(41/43例)和76.74%(33/43例),差异有统计学意义(P0.05)。治疗后,试验组和对照组的FVC分别为(2951.03±107.21),(2041.62±112.24)m L;FEV1分别为(2014.85±102.19),(1523.65±102.21)m L;MMF分别为(2.52±0.46),(2.14±0.38)L·s~(~(-1));MVV分别为(64.36±3.17),(55.74±3.26)L,差异均有统计学意义(均P0.05)。2组患儿的药物不良反应主要为嗜睡、腹泻、心率减缓、口干、头晕,试验组和对照组的药物不良反应发生率分别为23.26%和18.60%,差异无统计学意义(P0.05)。结论西替利嗪口服溶液联合布地奈德混悬液治疗小儿急性哮喘的临床疗效确切,可显著提高患儿的肺功能,且不增加药物不良反应的发生率。
[Abstract]:Objective to observe the efficacy and safety of cetirizine combined with budesonide suspension in the treatment of children with acute asthma. Methods 86 children with acute asthma were randomly divided into control group (n = 43) and experimental group (n = 43). The control group was given budesonide 1.0 mg bid every time for 15 minutes, and the experimental group was given cetirizine oral solution for 10 m Lbidbidin for 7 days on the basis of the treatment in the control group. The clinical efficacy, forced vital capacity (FV), forced expiratory volume (FEV1), forced midexpiratory flow (MMFV), maximum ventilation volume (MVV) and adverse drug reactions were compared between the two groups. Results after treatment, the total effective rates of the test group and the control group were 95.35 / 41 / 43 and 76.7474 / 33 / 43, respectively. The difference was statistically significant (P 0.05). After treatment, the FVC of the test group and the control group were 2951.03 卤107.21, 2041.62 卤112.24mL / L FEV1, respectively, and the FVC of the test group and the control group were 2014.85 卤102.19m / L, 1523.65 卤102.21m / L respectively (2.52 卤0.462.14 卤0.38L / L). The FVC of the test group and the control group were 64.36 卤3.1755.74 卤3.26L, respectively, and the difference was statistically significant (P0.05.2). The main adverse drug reactions were drowsiness, diarrhea, heart rate reduction, dry mouth, dizziness, dizziness and dizziness. The incidence of adverse drug reactions in the test group and the control group were 23.26% and 18.60%, respectively, with no significant difference (P 0.05). Conclusion Cetirizine oral solution combined with budesonide suspension is effective in the treatment of children with acute asthma. It can significantly improve the pulmonary function of children and does not increase the incidence of adverse drug reactions.
【作者单位】：台州市立医院儿科;
【基金】：浙江省医药卫生科技计划基金资助项目(2015KYB430)
【分类号】：R725.6

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