柯萨奇病毒A6型所致手足口病流行特征分析

发布时间：2018-05-03 14:53

本文选题：CV + EV　；参考：《中国病原生物学杂志》2017年11期

【摘要】：目的对柯萨奇病毒A6型(CA6)所致手足口病患儿流行特征及临床表现进行分析,为该病的预防控制提供科学依据。方法收集2016年1~12月海南省妇幼保健院儿科手足口病患儿的临床资料进行描述性流行病学分析;采集患儿肛拭子标本,使用荧光定量PCR试剂盒进行病毒核酸检测,分析其结果。结果 1 368例手足口病患者中检出EV71感染287例(占20.98%),CA16感染228例(占16.67%),CA6感染179(占13.08%%)。CA6感染组男女比例为1.89∶1,CA16感染组男女比例为1.23∶1差异有统计学意义(χ~2=4.620,P0.05);CA6感染组平均年龄为(2.91±2.12)岁,EV71及CA16感染者平均年龄分别为(3.49±2.19)岁和(3.38±2.11)岁,差异均有统计学意义(P0.05);CA6组皮疹易出现在躯干,与其他两组相比差异有统计学意义(χ~2=9.568,P0.05);CV6组与EV71组相比皮疹较少出现在足部,两组间差异有统计学意义(χ~2=5.614,P0.05);CA6组发热率75.61%,与EV71组(51.22%)和CA16(47.37%)比较差异均有统计学意义(χ~2=23.339,P0.05);EV71组和CA16组病例主要集中发生在4~8月份,CA6组主要发生在7~10月,差异有统计学意义(P0.05)。结论 CA6为儿童手足口病新的流行病原之一,其发病的平均年龄较小,多数患儿有发热症状,皮疹呈多样性,且多出现在躯干,流行高峰期为7~11月份。
[Abstract]:Objective to analyze the epidemic characteristics and clinical manifestations of children with hand foot and mouth disease (HFMD) caused by coxsackievirus A6 (CA6), and to provide scientific basis for the prevention and control of the disease. Methods the clinical data of children with hand foot and mouth disease in Hainan maternal and child health care hospital of 2016 were collected and analyzed by descriptive flow disease analysis, and the specimens of children's anal swabs were collected and used. The results showed that 287 cases (20.98%) were detected in 1368 cases of hand foot and mouth disease, 228 cases of CA16 infection (16.67%), 179 of CA6 infection (13.08%%).CA6 infection group of 1.89: 1 in 1368 cases of hand foot and mouth disease, and the proportion of men and women in CA16 infection group was 1.23: 1 (P0. (P0.), P0. (P0.). 05): the average age of CA6 infection group was (2.91 + 2.12) years, the average age of EV71 and CA16 infected people was (3.49 + 2.19) years and (3.38 + 2.11) years, the difference was statistically significant (P0.05). The skin rash in CA6 group was easy to appear in the trunk, compared with the other two groups (x ~2=9.568, P0.05); CV6 group was less in foot rash compared with EV71 group. The difference between the two groups was statistically significant (x ~2=5.614, P0.05), the fever rate in group CA6 was 75.61%, compared with group EV71 (51.22%) and CA16 (47.37%), there were statistical significance (x ~2=23.339, P0.05), EV71 and CA16 group cases mainly occurred in 4~8 month, CA6 group occurred mainly in 7~10 month, the difference was statistically significant. Conclusion the conclusion is children. One of the new epidemic pathogens of hand foot and mouth disease, the average age of the disease is smaller, most of the children have fever symptoms, skin rash is diversity, and more in the trunk, the peak of epidemic is 7~11 month.

【作者单位】：海南省妇幼保健院;
【分类号】：R181.3;R725.1

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