血清维生素D水平与婴幼儿反复喘息的相关性

发布时间：2018-05-04 14:17

本文选题：婴幼儿 + 反复喘息　；参考：《广东医学》2017年23期

【摘要】：目的研究血清维生素D水平与婴幼儿反复喘息的相关性,初步探讨其机制。方法采用酶联免疫吸附法(ELISA)测定78例反复喘息的婴幼儿(反复喘息组)及80例健康对照儿童(对照组)血清25-羟维生素D_3[25-(OH)D_3]、γ干扰素(IFN-γ)、白细胞介素-4(IL-4)水平,免疫比浊法测定总Ig E(TIg E)水平,分析反复喘息婴幼儿的维生素D水平与Th1/Th2平衡变化、TIg E水平的相关性。结果反复喘息组婴幼儿的血清25-(OH)D_3水平以及IFN-γ水平明显低于对照组[(19.85±7.64)ng/m L vs(41.13±13.71)ng/m L,(16.72±4.63)pg/m L vs(27.03±7.16)pg/m L;P=0.000];而前者血清IL-4、TIg E水平均明显高于后者[(39.63±21.32)pg/m L vs(9.53±4.27)pg/m L,(165±17)IU/m L vs(48±12)IU/m L;P=0.000]。反复喘息组婴幼儿Th1/Th2为0.48±0.23,对照组Th1/Th2为2.94±1.36,两组比较差异有统计学意义(t=-10.746,P=0.000)。反复喘息组婴幼儿血清25-(OH)D_3水平与Th1/Th2、TIg E均呈明显负相关(r=-0.809、-0.725,P=0.001)。结论反复喘息婴幼儿存在低维生素D水平,维生素D水平可能是导致反复喘息婴幼儿Th1/Th2免疫失衡的主要原因。
[Abstract]:Objective to study the correlation between serum vitamin D level and infant recurrent wheezing. Methods the serum levels of 25-hydroxyvitamin D3 [25-(OH)D_3], IFN- 纬, IL-4IL-4 were measured by Elisa in 78 infants with recurrent wheezing (wheezing group) and 80 healthy children (control group). The level of total Ig E(TIg E was determined by immunoturbidimetry, and the correlation between vitamin D level and Th1/Th2 balance was analyzed. Results the levels of serum 25-(OH)D_3 and IFN- 纬 in the recurrent wheezing group were significantly lower than those in the control group [19.85 卤7.64)ng/m L vs(41.13 卤13.71)ng/m vs(41.13 16.72 卤4.63)pg/m L vs(27.03 卤7.16)pg/m P 0.000], while the serum levels of IL-4tIg E in the former group were significantly higher than those in the latter group [39.63 卤21.32)pg/m L vs(9.53 卤4.27)pg/m L165 卤17)IU/m L vs(48 卤12)IU/m LU 0.000]. Th1/Th2 was 0.48 卤0.23 in the recurrent wheezing group and 2.94 卤1.36 in the control group. The difference between the two groups was statistically significant. In recurrent wheezing group, the serum 25-(OH)D_3 level was negatively correlated with Th1 / Th2 + TIg E. Conclusion there is low vitamin D level in recurrent wheezing infants, and vitamin D level may be the main cause of Th1/Th2 immune imbalance in recurrent wheezing infants.
【作者单位】：中山大学附属第三医院儿科;
【基金】：广东省自然科学基金面上项目(编号:S2013010016330) 广东省科技计划项目(编号:2013B021800082)
【分类号】：R725.6

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