2015-2016年深圳市龙华区手足口病流行病学和病原学特征

发布时间：2018-05-05 13:14

本文选题：手足口病 + 肠道病毒A型　；参考：《中华疾病控制杂志》2017年07期

【摘要】：目的本研究对深圳市龙华区手足口病(hand-foot-and-mouth disease,HFMD)的流行病学和病原学特征进行分析,为辖区HFMD预防和控制策略的制订提供重要科学依据。方法从中国疾病预防控制信息系统获取深圳市龙华区2015-2016年HFMD流行病学数据;采用荧光定量聚合酶链反应(reverse transcription-polymerase chain reaction,RT-PCR)方法对辖区447例HFMD进行肠道病毒(enteroviurs,EV)、肠道病毒71型(enteroviurs 71,EV-A71)和柯萨奇病毒A16(coxsackievirus A16,CV-A16)核酸检测,并对非EV-A71非CV-A16的其他肠道病毒进行VP1区序列亚型鉴定和进化分析。采用X~2检验对不同年龄层的HFMD病原体分型结果进行分析。结果2015-2016年深圳市龙华区HFMD发病率较高的两个街道分别是龙华街道和观澜街道;发病曲线呈双峰分布,5~7月份为主高峰,9~11月份为次高峰;5岁及以下儿童占全部发病数的96.40%;不同年龄层HFMD病原体分型结果的差异有统计学意义(X~2=25.01,P0.001)。结论 CV-A6为2015-2016年龙华区HFMD的主要病原,2015年流行的CV-A6存在两条支系。而2016年CV-A6存在多条支系。应重点做好5岁及以下儿童的手足口病防治工作。
[Abstract]:Objective to analyze the epidemiological and etiological characteristics of hand-foot-and-mouth disease (HFMD) in Longhua District, Shenzhen City, and to provide an important scientific basis for the formulation of HFMD prevention and control strategy. Methods the epidemiological data of HFMD from 2015 to 2016 in Longhua District of Shenzhen City were obtained from China Disease Prevention and Control Information system. A total of 447 cases of HFMD were detected by fluorescence quantitative polymerase chain reaction reverse transcription-polymerase chain reactionation assay (RT-PCR). Enteroviurs 71 EV-A71) and Coxsackie virus A16(coxsackievirus A16 CV-A16) nucleic acid were detected. Other non-EV-A71 non-CV-A16 enteroviruses were identified by VP1 sequence subtype identification and phylogenetic analysis. The results of HFMD pathogen typing in different age groups were analyzed by X2 test. Results from 2015 to 2016, the two streets with high incidence of HFMD in Longhua District of Shenzhen City were Longhua Street and Guanlan Street respectively. The incidence curve showed a bimodal distribution in July, the main peak in July was the second peak in September and November, the number of children aged 5 years or less accounted for 96.40% of the total incidence, and the difference of HFMD pathogen typing results among different age groups was statistically significant (P 0.001). Conclusion CV-A6 is the main pathogen of HFMD in Longhua district from 2015 to 2016, and there are two branches of CV-A6 in 2015. There are many branches of CV-A6 in 2016. Emphasis should be placed on the prevention and treatment of hand, foot and mouth disease in children under 5 years of age.
【作者单位】：深圳市龙华区疾病预防控制中心龙华新区传染病预防控制重点实验室;
【基金】：深圳市龙华新区科技创新资金项目(20160919A1030214)
【分类号】：R181.3;R725.1

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