孕妇IgG效价与不同血型新生儿溶血并发症的相关性分析

发布时间：2018-05-06 07:09

  本文选题：孕妇IgG效价 + 不同血型　； 参考：《中国实验血液学杂志》2017年05期

【摘要】：目的:探讨孕妇IgG效价与不同血型新生儿患溶血病(hemolytic disease of newborn,HDN)的相关性。方法:选取2014年5月-2015年1月在我院进行产检的O型血孕妇400例,且夫妻双方血型不同,在检查过程中对孕妇的IgG效价进行了检测,并且追踪孕妇产后新生儿溶血病的发生情况;根据新生儿是否出现HDN分为两组:HDN组和非HDN组。HDN组85例,非HDN组315例,并对IgG效价与其相关性进行系统的研究分析。结果:将产检过程中孕妇IgG效价分为1∶64、1∶64、1∶128、1∶256和1∶512 5组,对IgG效价64 4组的新生儿HDN发病率与IgG效价64的新生儿HDN发病率分别比较显示,ABO-HDN的患病率分别为96.9%、79.6%、63.7%和28.8%,孕妇IgG效价与新生儿ABO溶血病的发生存在着一定的相关性,即随着IgG效价的升高,新生儿溶血病的发病率有升高的趋势(r=0.8832)。4组中新生儿的HDN发病的风险均高于IgG效价64新生儿的HDN组。结论:孕妇IgG效价与ABOHDN的发病率有一定的相关性,因此对于IgG效价高的孕妇在产前进行效价的控制对于降低新生儿溶血病的发病率具有重要的临床意义。
[Abstract]:Objective: to investigate the relationship between IgG titer of pregnant women and hemolytic disease of newbornus in newborns with different blood groups. Methods: 400 pregnant women with type O blood were selected from May 2014 to January 2015, and their blood groups were different. The IgG titer of pregnant women was detected during the examination. According to the occurrence of neonatal hemolytic disease in pregnant women, HDN was divided into two groups: HDN group (n = 85), non-HDN group (n = 85) and non-HDN group (n = 315). The relationship between IgG titer and its correlation was analyzed systematically. Results: the IgG titers of pregnant women were divided into 1: 64: 1: 64: 1: 1: 128 1: 256 and 1: 512 5 groups. The incidence of HDN in neonates with IgG titer 64 and HDN in newborns with IgG titer 64 showed that the prevalence rate of ABO-HDN was 96.90.79. 6% and 28.887%, respectively. There was a certain correlation between IgG titer of pregnant women and the occurrence of ABO hemolytic disease in neonates. That is, with the increase of IgG titer, the incidence of hemolytic disease in neonates has a tendency to increase. The risk of neonatal HDN in group R 0.8832 4 is higher than that in HDN group with IgG titer of 64 neonates. Conclusion: the IgG titer of pregnant women is related to the incidence of ABOHDN, so it is of great clinical significance to control the titer of pregnant women with high IgG titer in prenatal to reduce the incidence of neonatal hemolysis.
【作者单位】： 湖北省襄阳市中心医院输血科;
【基金】：湖北省卫生计生采供血基金资助项目(WJ2015CB011)
【分类号】：R722.18

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