血清炎性因子、血小板相关指标单独及联合检测对新生儿细菌感染性败血症的诊断价值

发布时间：2018-05-07 01:33

本文选题：败血症 + 细菌　；参考：《山东医药》2017年02期

【摘要】：目的探讨血清炎性因子、血小板相关指标单独及联合检测对新生儿细菌感染性败血症的诊断价值。方法选取细菌感染性败血症新生儿60例(败血症组)、非感染性疾病新生儿30例(对照组),检测血清白细胞介素6(IL-6)、IL-8、降钙素原(PCT)、C反应蛋白(CRP)及血小板计数(PLT)、血小板体积(MPV)。结果败血症组IL-6、IL-8、PCT、CRP、MPV高于对照组(P均0.05),PLT低于对照组(P0.05);IL-6、IL-8、PCT、CRP、PLT、MPV单一指标诊断新生儿细菌感染性败血症的灵敏度分别为83.33%、73.33%、88.33%、96.67%、78.33%、96.67%,特异度分别为73.33%、63.33%、83.33%、53.33%、63.33%、76.67%,IL-6+IL-8+PCT+CRP、PLT+MPV、IL-6+IL-8+PCT+CRP+PLT+MPV联合检测诊断灵敏度分别为58.33%、68.33%、35.00%,特异度分别为80.00%、73.33%、96.67%。结论多种血清炎性因子联合血小板相关指标检测能明显提高新生儿细菌感染性败血症诊断特异度,但敏感度不及单一指标检测。
[Abstract]:Objective to investigate the diagnostic value of serum inflammatory factors and platelet related indexes in neonatal bacterial septicemia. Methods 60 neonates with bacterial septicemia (septicemia group) and 30 neonates with non-infectious diseases (control group) were selected. The serum levels of IL-8, procalcitonin (PCT) -reactive protein (CRP), platelet count (PLT) and platelet volume (MPV) were measured. Results in septicemia group, the sensitivity of IL-6, IL-8, IL-8, PCT, CRP, MPV, MPV was higher than that in control group (P = 0.05, P < 0.05). The sensitivity of the single index of IL-6, PCT, CRP, PLT, MPV in diagnosing neonatal bacterial septicemia was 83.338.3388.3396.336.67, and the specificity was 73.3363.333.3353.3353.3353.3353.3353.3353.3353.3353.3353.3353.3353.33, respectively. The degree of 58.33 and 68.33 were 35.00, and the specificity was 80.000 and 73.33, respectively. Conclusion the detection of various serum inflammatory factors combined with platelet related indexes can improve the diagnostic specificity of neonatal bacterial septicemia, but the sensitivity is less than that of single index.
【作者单位】：重庆医科大学附属儿童医院;
【基金】：国家临床重点专科建设项目(国卫办医2013-544号)
【分类号】：R722.131

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