免疫球蛋白佐治婴幼儿肺炎的效果及对患儿免疫功能水平的影响

发布时间：2018-05-11 21:38

本文选题：免疫球蛋白 + 重症肺炎　；参考：《中国免疫学杂志》2017年06期

【摘要】：目的:探讨静脉注射免疫球蛋白结合常规疗法治疗婴幼儿重症肺炎的临床效果及对患儿免疫功能水平的影响作用。方法:选取2015年1月~2016年4月在本院儿科进行治疗的88例重症肺炎患儿进行回顾性分析,其中47例患儿采用常规治疗+静脉注射免疫球蛋白(治疗组)、41例患儿仅采取常规疗法(对照组),疗程2周。结果:治疗组患儿的发热、呼吸困难、咳嗽、喘息、肺部罗音的消失时间均短于对照组患儿,差异均具有统计学意义(P0.05);治疗2周后,治疗组患儿的Ig G水平均高于对照组患儿,差异均具有统计学意义(P0.05);治疗2周后,治疗组患儿的血清IL-6、TNF-α、WBC、中性粒细胞、单核细胞水平均低于对照组患儿,差异均具有统计学意义(P0.05);治疗1周后,治疗组的痊愈率57.45%高于对照组的34.15%(P0.05);治疗组的显效率42.55%与对照组的60.98%差异无统计学意义(P0.05)。结论:静脉注射免疫球蛋白结合常规疗法治疗婴幼儿重症肺炎能够改善患儿的免疫功能水平,提高治疗效果。
[Abstract]:Objective: to investigate the clinical effect of intravenous immunoglobulin combined with routine therapy in the treatment of infant severe pneumonia. Methods: 88 children with severe pneumonia who were treated in pediatrics from January 2015 to April 2016 were retrospectively analyzed. Among them, 47 cases were treated with routine intravenous immunoglobulin (IVIG). 41 cases in the treatment group were treated with routine therapy only (control group, course of treatment 2 weeks). Results: the time of fever, dyspnea, cough, wheezing and disappearance of lung rales in the treatment group was shorter than that in the control group, the difference was statistically significant (P 0.05), the level of IgG in the treatment group was higher than that in the control group after 2 weeks of treatment. After 2 weeks of treatment, the levels of serum IL-6 TNF- 伪, neutrophils and monocytes in the treatment group were significantly lower than those in the control group (P 0.05), and after 1 week of treatment, the levels of IL-6 TNF- 伪, neutrophils and monocytes in the treatment group were significantly lower than those in the control group (P 0.05). The cure rate of the treatment group was 57.45% higher than that of the control group (34.15%, P 0.05), and the effective rate of the treatment group was 42.55%, which was not significantly different from that of the control group (60.98%). Conclusion: intravenous immunoglobulin combined with routine therapy can improve the level of immunological function and the therapeutic effect of infantile severe pneumonia.
【作者单位】：河南省中医院/河南中医药大学第二附属医院;河南中医药大学基础医学院;
【分类号】：R725.6

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