脐带血维生素D水平与新生儿生长指标的关系

发布时间：2018-05-12 12:10

本文选题：脐带血 + (OH)D　；参考：《临床儿科杂志》2017年06期

【摘要】：目的了解新生儿脐带血维生素D水平现况,探讨脐带血维生素D水平与新生儿生长指标的相关性。方法共纳入223对足月单胎母子。问卷法收集母亲孕期信息;测量新生儿出生体质量、头围和身长指标;采用酶联免疫法测定新生儿脐带血和母亲孕晚期血25(OH)D浓度。结果脐带血25(OH)D平均浓度为20.7 nmol/L,维生素D缺乏率达82.1%,其中严重缺乏率为12.1%(10 nmol/L)。子代与母亲孕晚期25(OH)D浓度基本一致。脐带血不同25(OH)D浓度新生儿的出生季节分布差异有统计学意义(P0.05),10 nmol/L组冬春季节所占比例较高。脐带血25(OH)D浓度与低出生体质量(LBW)和小于胎龄(SGA)新生儿的发生率均无显著相关(P0.05)。控制性别、胎龄、出生季节等变量后,脐带血不同25(OH)D浓度组间的出生体质量和头围差异有统计学意义(P0.05)。结论足月新生儿脐带血25(OH)D浓度普遍低,维生素D缺乏状态与其母亲孕晚期维生素D状况基本一致。脐带血25(OH)D浓度与新生儿出生体质量和头围存在一定相关性,其具体规律尚有待进一步扩大样本验证。
[Abstract]:Objective to investigate the present status of vitamin D levels in umbilical cord blood of neonates and to explore the correlation between vitamin D levels in umbilical cord blood and neonatal growth indicators. Methods 223 full-term single-born mothers and children were included. The maternal pregnancy information was collected by questionnaire, the birth weight, head circumference and body length of newborn were measured, and the 25(OH)D concentration of umbilical cord blood and maternal blood in late pregnancy were measured by enzyme-linked immunosorbent assay (Elisa). Results the average concentration of 25(OH)D in umbilical cord blood was 20.7 nmol / L, the rate of vitamin D deficiency was 82.1, and the rate of severe deficiency was 12.1nmol / L. The concentration of 25(OH)D in the offspring was basically the same as that in the mother in the third trimester. There was significant difference in the distribution of birth seasons among the newborns with different 25(OH)D concentrations in umbilical cord blood. The proportion of winter and spring seasons in 10 nmol/L group was higher than that in P0.05 nmol/L group. There was no significant correlation between 25(OH)D concentration in umbilical cord blood and the incidence of low birth weight (LBW) and small gestational age (SGA) neonates (P 0.05). After controlling for sex, gestational age and birth season, there were significant differences in birth weight and head circumference among groups with different 25(OH)D concentrations in umbilical cord blood (P 0.05). Conclusion the 25(OH)D concentration of umbilical cord blood in term neonates is generally low, and vitamin D deficiency is basically consistent with the status of vitamin D in late pregnancy. The 25(OH)D concentration in umbilical cord blood was correlated with the birth weight and head circumference of newborns.
【作者单位】：上海交通大学医学院附属上海儿童医学中心;上海交通大学医学院附属仁济医院产科;
【基金】：国家自然科学基金资助项目(No.81422040,81172685) 教育部新世纪优秀人才项目(No.NCET-13-0362) 科技部973培育项目(No.2010 CB 535000) 卫生部行业科研专项基金(No.201002006) 上海市科委项目及启明星追踪项目(No.12411950405,No.13QH1401800) 上海市教委曙光计划(No.11 SG 19)
【分类号】：R722.1

【相似文献】