CT测量肝脏体积指数评价胆道闭锁肝硬化程度的临床意义

发布时间：2018-05-14 08:27

本文选题：胆道闭锁 + 肝硬化　；参考：《青岛大学》2014年硕士论文

【摘要】：目的探讨CT测量肝脏体积指数(LVI)在胆道闭锁患儿肝硬化评估中的临床意义。方法收集2006年1月至2013年2月间在我院治疗的胆道闭锁患儿41例作为研究对象,肝纤维化程度采用Matavir分级,F0-F3为非肝硬化组,F4为肝硬化组；用64排螺旋CT测量肝脏体积(LV),并根据公式计算LVI；分析LVI与各血清学指标的相关性,并绘制LVI的受试者工作特征曲线(receiver operating characteristic curve),简称ROC曲线。结果肝硬化组和非肝硬化组LV测量值分别为148.65±28.98cm3,185.56±33.68cm3；LVI分别为0.74±0.09,0.86±0.07。肝硬化组LVI明显低于非肝硬化组,两组LVI差异有显著统计学意义(t=-4.15,P0.05)；肝硬化组患儿年龄高于非肝硬化组,且差异有统计学意义(P0.05)；LVI与AST呈显著负相关(r=-0.44,P0.05)；LVI与PLT呈显著正相关(r=0.47,P0.05)；绘制LVI的ROC曲线,曲线下面积为0.88,选择LVI为0.84作为诊断界点时,其敏感度为91%,特异度为83%。结论LVI可准确的反应胆道闭锁患儿LV变化的程度,对于评价胆道闭锁患儿的肝硬化程度有较高准确性和可靠性,可用于预测预后和提早做好肝移植准备。
[Abstract]:Objective to investigate the clinical significance of hepatic volume index (LVI) measured by CT in the assessment of liver cirrhosis in children with biliary atresia. Methods 41 children with biliary atresia who were treated in our hospital from January 2006 to February 2013 were studied. The degree of hepatic fibrosis was treated with Matavir grade F0-F3 as non-cirrhosis group and F4 as cirrhosis group. The volume of liver was measured by 64-slice spiral CT, and the LVI was calculated according to the formula. The correlation between LVI and each serological index was analyzed, and the operating characteristic curve of LVI was plotted. The receiver operating characteristic curve (ROC curve) was drawn. Results the LV values of cirrhosis group and non-cirrhosis group were 148.65 卤28.98cm3185.56 卤33.68 cm 3 and 0.74 卤0.09 卤0.86 卤0.07, respectively. The LVI of cirrhosis group was significantly lower than that of non-cirrhosis group, the difference of LVI between the two groups was statistically significant, the age of cirrhosis group was higher than that of non-cirrhosis group, the difference between the two groups was statistically significant. There was a significant negative correlation between LVI and AST. There was a significant positive correlation between LVI and PLT. The ROC curve of LVI was 0.88, and when LVI was 0.84, the sensitivity was 91 and the specificity was 833. Conclusion LVI can accurately reflect the degree of LV changes in children with biliary atresia and has high accuracy and reliability in evaluating the degree of cirrhosis in children with biliary atresia. It can be used to predict prognosis and prepare for liver transplantation.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R725.7

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