肺炎支原体合并Epstein-Barr病毒感染患儿的临床特征及免疫状况分析

发布时间：2018-05-14 06:10

  本文选题：儿童 + 肺炎支原体　； 参考：《中华医院感染学杂志》2017年18期

【摘要】：目的探讨肺炎支原体合并Epstein-Barr病毒感染患儿的临床特征及免疫状况。方法选择2015年1月-2016年12月医院肺炎支原体合并Epstein-Barr病毒感染患儿80例作为实验组,另选取肺炎支原体未合并Epstein-Barr病毒感染患儿80例作为对照组,收集两组患儿的临床表现、实验室检查结果、影像学检查结果、免疫指标等资料。结果实验组患儿重症肺炎发生率为31.25%高于对照组6.25%(P0.05),实验组发热时间和住院时间分别为(13.24±3.53)d、(13.98±4.21)d显著高于对照组(8.24±3.41)d、(9.78±4.04)d(P0.05),两组肝肿大和淋巴结肿大发生率比较差异无统计学意义;实验组白细胞升高33.75%、AST升高36.25%、CK-MB升高42.50%均高于对照组的12.50%、11.25%、13.75%(P0.05),两组血沉升高比例、CRP升高比例、降钙素原升高比例比较差异无统计学意义;实验组肺实变和胸腔积液的发生率分别为21.25%、30.00%高于对照组7.50%、10.00%(P0.05),两组肺炎类型比较差异无统计学意义;实验组CD_4~+细胞(24.31±12.14)%、CD_8~+细胞(13.76±7.98)%、CD_4~+细胞/CD_8~+细胞(1.77±0.76)、B细胞(8.96±1.87)%、NK细胞(4.24±0.78%)均低于对照组(54.64±13.64)%、(20.02±8.68)%、(2.73±1.17)、(14.78±2.13)%、(11.32±1.53)%(P0.05)。结论肺炎支原体合并Epstein-Barr病毒感染患儿病情更严重,肺炎支原体合并Epstein-Barr病毒感染对机体的损伤可能由免疫反应造成。
[Abstract]:Objective to investigate the clinical features and immune status of mycoplasma pneumoniae combined with Epstein-Barr virus infection in children. Methods from January 2015 to December 2016, 80 children with mycoplasma pneumoniae combined with Epstein-Barr virus infection were selected as experimental group and 80 children without mycoplasma pneumoniae infection with Epstein-Barr virus as control group. The clinical manifestations of the two groups were collected. Laboratory examination results, imaging results, immune indicators and other data. Results the incidence of severe pneumonia in the experimental group was 31.25% higher than that in the control group (6.25%, P 0.05). The febrile time and the hospitalization time in the experimental group were 13.24 卤3.53 d and 13.98 卤4.21 days, respectively, which were significantly higher than those in the control group (8.24 卤3.41). The incidence of hepatomegaly and lymphadenomegaly was not significantly different between the two groups. The increase of leukocyte and AST in the experimental group was 36.25% and the increase of CK-MB was 42.50%, which was higher than that of the control group (12.50%, 11.25%, 13.75%, P0.05%). There was no significant difference in the proportion of CRP and procalcitonin between the two groups. 瀹為獙缁勮偤瀹炲彉鍜岃兏鑵旂Н娑茬殑鍙戠敓鐜囧垎鍒�涓�21.25%,30.00%楂樹簬瀵圭収缁，

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